Jiangsu Huaiyu Pharmaceutical Co., Ltd.

Zte Corporation

Shanghai Pharmaexplorer Co., Ltd.

Shanghai Yunyi Healthcare and Technology Co., Ltd.

Jiangsu Hyamab Pharmaceutical Co., Ltd.

Shanghai Hyamab Biotech Co., Ltd.

Qing Duan

Lile Liu

Tatchi Teddy Yang

Shaoping Hu

Xinxiu Yang

Jian Yuan Wu

Hongzhuan Gu

Hu Liu

Zhengrong Shuai

Yuandong Wang

Qin Zhong

Mingming Pan

Xiaohui Shao

Haishan Luo

Jun Yang

Jian Wang

Jun Li

Peng Wang

Lina Xu

Qian Wang

Wei Shao

Meiling Wang

Yan Liu

Yanyan Li

Heng Pan

Shiyong Gong

Xiaodan Cao

Yingying Hu

Na Song

Lina Wang

Yizhen Yang

Xiaolan Sun

Yajun Huang

Zihan Jin

Ying Gu

Siran Zhu

Stewart Leung

Xiaoxuan Lan

Haohan Liu

Yingying Gao

Ningning Song

Lijuan Hao

Xiaojiao Bian

Peipei Wei

Provided are a murine or fully human monoclonal antibody targeting SEMA4D and a preparation method therefor, wherein the antibody binds to the SEMA4D antigen and has activities such as combating tumors.

SEMA4D antibody, preparation method therefor and use thereof

Disclosed in the present invention are an antibody targeting LAG-3, a preparation method therefor and the use thereof. In particular, disclosed in the present invention is a novel monoclonal antibody targeting LAG-3. Also disclosed in the present invention is a method for the preparation of the monoclonal antibody. The monoclonal antibody of the present invention is capable of binding LAG-3 antigens with high specificity, and has very high affinity and significant activities such as anti-tumor activity.

Anti-human LAG-3 monoclonal antibody and use thereof

Provided in the present invention are a 4-1BB antibody and a preparation method and the use thereof. In particular, provided in the present invention are a 4-1BB antibody, which has high affinity to 4-1BB protein, can effectively activate the signal downstream of the 4-1BB and significantly increase expression quantities of IFN-&#x3b3; and IL-2 in human mixed lymphocytes or T lymphocytes, and can be used to treat cancers and autoimmune diseases.

4-1BB antibody and preparation method and use thereof

The present invention discloses IL-13 antibody, method of its preparation and use thereof. The IL-13 antibody comprises one or more of heavy chain CDR1, heavy chain CDR2 and heavy chain CDR3 of heavy chain variable region of the IL-13 antibody, and/or one or more of light chain CDR1, light chain CDR2, and light chain CDR3 of light chain variable region of the IL-13 antibody. The IL-13 antibody has a high affinity and can significantly inhibit the secretion of thymus activation-regulated chemokine and periostin as well as the expression of vascular cell adhesion molecule-1 induced by IL-13, it can significantly inhibit airway hyperresponsiveness in mice induced by IL-13, and therefore can be used in the preparation of drugs for preventing or treating IL-13 expression or dysfunction related diseases.

IL-13 antibody and preparation method and use thereof

Anti-PD-1 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancers and autoimmune diseases.

Anti-PD-1 antibodies and uses thereof

Provided herein are anti-PD-L1 antibodies and antigen-binding fragments thereof. Also provided are nucleic acids encoding the antibodies, compositions containing the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer, infectious diseases and autoimmune diseases.

Anti-PD-L1 antibodies and uses thereof

The disclosure provides a quick positioning method and device for multiple cycles and multiple users, and the method includes: a processing index is created for each attribute of a user in a base station, wherein same attributes with the same transmission cycles and the same transmission offsets share one processing index; when a user accesses the base station, the user is mounted into a corresponding processing index according to an attribute of the user, a transmission cycle of the attribute, and a transmission offset of the attribute; and by inquiring a processing index corresponding to the current time point, the base station demodulates the attribute of the user mounted in said processing index. With the disclosure, a target can be hit promptly, processing time is saved, processing efficiency is improved, and the processing time delay of the whole link is reduced.

Quick positioning method and device for multiple cycles and multiple users

Growing community of inventors

Shanghai, China

Qing Duan