Shanghai Pharmaexplorer Co., Ltd.

Shanghai Yunyi Healthcare and Technology Co., Ltd.

Qin Zhong

Lile Liu

Qing Duan

Xinxiu Yang

Jian Wang

Jian Yuan Wu

Shaoping Hu

Tatchi Teddy Yang

Hongzhuan Gu

Shiyong Gong

Yizhen Yang

Haishan Luo

Hu Liu

Zhengrong Shuai

Lijuan Hao

Stewart Leung

The present invention discloses IL-13 antibody, method of its preparation and use thereof. The IL-13 antibody comprises one or more of heavy chain CDR1, heavy chain CDR2 and heavy chain CDR3 of heavy chain variable region of the IL-13 antibody, and/or one or more of light chain CDR1, light chain CDR2, and light chain CDR3 of light chain variable region of the IL-13 antibody. The IL-13 antibody has a high affinity and can significantly inhibit the secretion of thymus activation-regulated chemokine and periostin as well as the expression of vascular cell adhesion molecule-1 induced by IL-13, it can significantly inhibit airway hyperresponsiveness in mice induced by IL-13, and therefore can be used in the preparation of drugs for preventing or treating IL-13 expression or dysfunction related diseases.

IL-13 antibody and preparation method and use thereof

Anti-PD-1 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancers and autoimmune diseases.

Anti-PD-1 antibodies and uses thereof

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Shanghai, China

Qin Zhong