Sap Se

Fudan University

Qiming Xu

Yuefan Zhang

Tiejun Li

Hao Cheng

Yaocheng Rui

Susanne Hempel

Abdallah El Sahhar

Zhong Xian Hu

Boliang Chen

Jie Pan

Koichi Tsumoto

Takane Ozaki

Ute Weingart

Bowen Zhang

Zhen Cheng

Xiangshi Tan

Wendan Chen

Liufang Wu

Techniques and solutions are provided for a source quality check service configured to analyze source text and identify issues in the source text. The source quality check service may identify the issues by performing a selected subset of checks with a centralized source quality check engine, and may be called from within one or more of an Integrated Development Environment (IDE), a build process, and/or a translation process to perform the selected subset of checks. The source quality check service may be further configured to output a report of the identified one or more issues.

Source quality check service

The present invention belongs to the field of medicine technology, particularly relating to an application of cyclic dinucleotide (cGAMP) in tumor treatment. Researches carried out in the present invention show that, cGAMP can inhibit growth of many types of tumor cells, with remarkable anti-tumor effect, thus, it can be used in preparation of anti-tumor drugs; and the prepared anti-tumor drugs have low toxicity and favorable effect. Proved by a subcutaneous tumor model in nude mice, cGAMP has a remarkable inhibition effect on tumors of human gastric carcinoma cell line MNK-45, human lung adenocarcinoma cell line A549, human colorectal carcinoma cell line Lovo, human hepatocellular carcinoma cell line SMMC-7721, human prostatic carcinoma cell line PC-3 and human pancreatic carcinoma cell SW1990, which are subcutaneously implanted in nude mice, and also proved by animal acute toxicity experiment. cGAMP has a relatively low acute toxicity, therefore and may be used for preparing anti-tumor drugs.

Application of cyclic dinucleotide (cGAMP) in anti-tumor field

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Shanghai, China

Qiming Xu