Dow Agrosciences LLC

Sangamo Biosciences, Inc.

Sangamo Therapeutics, Inc.

Qihua C Cai

Joseph F Petolino

Jeffrey C Miller

Robbi J Garrison

Fyodor Urnov

Sarah E Worden

Nicole Arnold

Vipula Shukla

Ryan C Blue

Jon Christopher Mitchell

Lisa W Baker

Donald J Merlo

Aaron Todd Woosley

Timothy Denver Hey

Thomas Meade

Joel Jay Sheets

Stephanie L Burton

William M Ainley

Andrew F Worden

Beth C Rubin-Wilson

Lisa L Schulenberg

Haley Jo Moon

Jeffrey A Miller

Weiting W Ni

Jeffrey Miller

Jon C Mitchell

Andrew Frederick Worden

Robbi Janette Garrison

Beth Cori Rubin-Wilson

Lisa Lynn Schulenberg

Nicole L Arnold

Vipula K Shukla

William Michael Ainley

Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into a predetermined target site in a plant genome.

Zinc finger nuclease-mediated homologous recombination

Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.

Optimized non-canonical zinc finger proteins

The present invention relates to methods and compositions for the expression of protein. Embodiments of methods may comprise the cleavage and repair of a nucleotide sequence encoding a highly expressed protein leading to a reduction in the expression of the highly expressed protein.

Protein production in plant cells and associated methods and compositions

The subject invention relates to insecticidal toxin complex ('TC') fusion proteins and to polynucleotides that encode these fusion proteins. In some embodiments, the invention provides a fusion protein comprising a Class A protein, a Class B protein, and a Class C TC protein fused together to form a single protein. In some other embodiments, the invention provides a fusion protein comprising a Class B and a Class C TC proteins fused together. In the latter embodiments, the BC or CB fusion protein can be used to enhance or potentiate the anti-insect activity of a 'Toxin A' or Class A protein. The subject invention also includes plants, cells (bacterial and plant cells for example), and seeds that comprise the polynucleotides. The subject invention also includes methods of controlling pests (preferably insects and other plant pests) with fusion proteins of the subject invention.

Insecticidal toxin complex fusion protiens

The subject invention relates to insecticidal toxin complex ('TC') fusion proteins and to polynucleotides that encode these fusion proteins. In some embodiments, the invention provide a fusion protein comprising a Class A protein, a Class B protein, and a Class C TC protein fused together to form a single protein. In some other embodiments, the invention provides a fusion protein compromising a Class B and a Class C TC proteins fused together. In the latter embodiments, the BC and CB fusion protein can be used to enhance or potentate the anti-insect activity of a 'Toxin A' or Class A protein. The subject invention also includes plants, cells (bacterial and plant cells for example) and seeds that comprise the polynueleotides. The subject invention also includes methods of controlling pests (preferably insects and other plant pests) with fusion proteins of the subject invention.

Insecticidal toxin complex fusion proteins

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Westfield, IN, United States of America

Qihua C Cai