Genentech, Inc.

William Robert Arathoon Living Trust Dated August 29, 2016

F. Hoffmann-la Roche Ag

Qianting Zhai

Paul J Carter

Raffaella Briante

Suchismita Mohanty

Paul David Ponath

Cindy Tan

Evan Matthew Bishop

William Robert Arathoon

Alissa Loren Briggs

Provided are multi-specific antibodies that target both a cellular efflux pump and a cancer-associated antigen as well as pharmaceutical compositions, nucleic acids, recombinant expression vectors, cells, and kits that include or encode such multi-specific antibodies. Methods of treating a subject for a cancer that include administering to the subject a multi-specific antibody that targets both a cellular efflux pump and a cancer-associated antigen are also provided. Provided as well are methods of generating the described multi-specific antibodies and reagents related thereto, including genetically modified cell lines useful in the subject methods and methods of making such genetically modified cell lines.

Efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto

The invention provides anti-hypusine antibodies and their use in detecting and isolating polypeptides containing hypusine and/or deoxyhypusine, as well as compositions and kits comprising the anti-hypusine antibodies.

Anti-hypusine antibodies and uses thereof

Growing community of inventors

South San Francisco, CA, United States of America

Qianting Zhai