Nantong University

Qianru He

Xiaosong Gu

Xin Tang

Cheng Sun

Gang Chen

Fei Ding

Yumin Yang

Hongkui Wang

Mi Shen

Haoming Li

Xiaokun Gu

Wenfeng Su

Tianmei Qian

Yanpei Gong

Xisosong Gu

Ag&#x2014;Fe3O4 immunomagnetic microsphere contains poly-D-lysine modified on the surface and S100&#x3b2; and/or MBP antibody linked by an amide bond. The Ag&#x2014;Fe3O4 immunomagnetic microsphere can specifically capturing peripheral nerve tissue-derived exosomes. When the microsphere is used to extract nerve tissue-derived exosomes, the extraction yield of exosomes per unit volume of nerve tissue is high, and the nerve specificity is strong.

Method for extracting nerve tissue-derived exosomes

A differential tissue-engineered nerve including motor-like nerves and sensory-like nerves. The motor-like nerve and the sensory-like nerve respectively includes a motor-like nerve outer tube and a motor-like nerve fiber in the outer tube as well as a sensory-like nerve outer tube and a sensory-like nerve fiber in the outer tube. Schwann cells and/or fibroblasts derived from motor nerves and sensory nerves are respectively contained in surfaces or pores of the motor-like and sensory-like nerve outer tubes. Transsynaptic signal molecules Neuroligin-1 and Neuroligin-2 are contained in surfaces or pores of the motor-like and sensory-like nerve fibers. Neuroligin-1 is selectively used to specifically promote synaptic remodeling of motor neurons, while Neuroligin-2 is selectively used to specifically promote synaptic remodeling of sensory neurons, so that repair efficiency of motor nerve cells and sensory nerve cells is improved.

Construction and application of differentially regulated tissue-engineered nerve grafts

Growing community of inventors

Jiangsu, China

Qianru He