Sichuan University

Qianming Chen

Hang Zhao

Yang He

Jiang Liu

Xin Zeng

Lu Jiang

Jian Song

Hang Wang

Lideng Cao

Yuqi Du

Hui Feng

Ning Ji

A supramolecular hydrogel capable of delivering lipophilic medicaments, a preparation method therefor, and uses thereof are provided. The structure of the supramolecular hydrogel is represented by Formula I, in which Rand Rare each independently selected from palmitoyl or oleoyl, respectively. The hydrogel can be used as a drug delivery system, and encapsulate and load various medicaments. In particular, it has good controlled-release for hydrophobic medicaments.

Supramolecular hydrogel for lipophilic drug delivery, a preparation method therefor, and use thereof

A bifunctional nucleoside hydrogel is formed by dissolving isoguanosine, guanosine and a borate in water or an aqueous solution and then crosslinking same. The bifunctional nucleoside hydrogel integrates a carrier and a drug effect and has a significant inhibitory effect on the activity of tumor cells, and in particular has a significant inhibitory effect on the activity of cells related to lung cancer, glioma, osteoma, colon cancer, breast cancer, oral squamous cell carcinoma and tongue squamous cell carcinoma, of which the inhibitory effect on the activity of cells related to oral squamous cell carcinoma is the best. Therefore, the bifunctional nucleoside hydrogel has potential application prospects in preparing anti-tumor drugs, and particularly, same can provide a new approach for treating oral squamous cell carcinoma.

Bifunctional nucleoside hydrogel, preparation method therefor and use thereof

Provided is use of a pyrimidine compound or a pharmaceutically acceptable salt thereof in preparation of an anti-cervical cancer medicament. Research of the present invention has found that the above-mentioned pyrimidine compound can be effective against cervical cancer, and has a good inhibition effect on E6 and E7 of HPV16, and indicates that the above-mentioned pyrimidine compound also has a good anti-human papilloma virus effect, providing a new choice for clinical medication.

Pyrimidine compounds and use as anti-cervical cancer thereof

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Sichuan, China

Qianming Chen