Xtl Biopharmaceuticals Ltd.

Vivoquest, Inc.

Qiang Zhu

Reza Fathi

Zhen Yang

Anthony Sandrasagra

Yixin Liu

Hyun-Joon Cho

C Richard Wobbe

Jie Wu

Yun Liao

Kenneth Nawoschik

Bin Xu

Guolin Li

Angela Lam

Jie Cao

Wu Ruoqiu

Lisha Wang

The present invention relates to 4-thio substituted quinoline and naphthyridine derivatives and processes for their preparation. The invention also related to methods for treating infection of Hepatitis C virus by administering a 4-thio substituted quinoline or naphthyridine derivative.

4-thio substituted quinoline and naphthyridine compounds

The present invention relates to 3,4-disubstituted coumarin and quinolone derivatives and processes for their preparation. The invention also related to methods for treating infection of Hepatitis C virus by administering a 3,4-disubstituted coumarin or quinolone derivative.

3,4-disubstituted coumarin and quinolone compounds

Aryl substituted pyrazole derivatives are provided, as well as processes for their preparation. The invention also provides compositions and methods for the treatment of HCV by administering a compound of the present invention, alone or in combination with additional antiviral agents, in a therapeutically effective amount.

4-ethynyl pyrazole derivative compounds and methods for treatment of HCV

4-Thio substituted coumarin derivatives, 4,5-dithio substituted coumarin derivatives, and coumarin dimers are provided, as well as processes for their preparation. The invention also provides a method and composition for the treatment of hepatitis C virus (HCV) by adiministering 4-thio substituted coumarin derivatives, 4,5-dithio substituted coumarin derivatives, and coumarin dimers.

4-thio coumarins

4-thio substituted coumarin derivatives and coumarin dimers are provided, as well as processes for their preparation. A synthetic process for the preparation of 4-thio substituted coumarin derivatives is provided using mild reaction conditions, which maintains a high substituent tolerance and is appropriate for use in solid phase syntheses for producing a library of 4-thio substituted coumarin derivatives for biological screening.

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Edson, NJ, United States of America

Qiang Zhu