Xi'an Zhongxing New Software Co., Ltd.

Shenzhen Ruijian Bioscience Technology Limited Company

Qiang Zhou

Shupeng Li

Zheng Peng

Peng Xia

The present invention provides a polypeptide capable of crossing the blood-brain barrier. In the present invention, C-terminal of the ziconotide is linked to N-terminal of a cell membrane penetrating peptide via one glycine to obtain a polypeptide capable of crossing the blood-brain barrier. The polypeptide of the present invention is suitable for intravenous, intraperitoneal or nasal administration with convenient operation and low clinical risk. It has a long pharmacological effect in vivo, excellent analgesic effect, and slight peptide side effect after intravenous, intraperitoneal or nasal administration, and is suitable for large-scale clinical applications. The polypeptide of the invention has the advantages of simple preparation, controllable preparation process and quality during the preparation, and is suitable for large-scale industrial production.

Polypeptide capable of passing through blood-brain barrier

The present disclosure provides an integration method for multiple centralized units, an integration device for multiple centralized units, and an integration system for multiple centralized units. The integration system for multiple centralized units includes a centralized unit center, the centralized unit center is configured to integrate multiple logical centralized units, the multiple logical centralized units share one or more function modules at corresponding levels according to a preset service requirement, and the function modules at the corresponding levels are configured to provide function services at the corresponding levels for the logical centralized units.

Growing community of inventors

Guangdong, China

Qiang Zhou