Dow Agrosciences LLC

Other

Eli Lilly and Company

Chugai Seiyaku Kabushiki Kaisha

Dow Argosciences LLC

Corteva Agriscience LLC

Qiang Yang

Beth Lorsbach

Gary A Roth

Carl Vincent DeAmicis

Kaitlyn C Gray

Yu Zhang

Joseck M Muhuhi

Xiaoyong Li

Gregory T Whiteker

Ronald Ross, Jr

David E Podhorez

Greg Whiteker

Thomas P Clark

Ann Marie Buysse

Elisabeth J Kane

Belgin Canturk

Jeffrey S Nissen

Noormohamed Mohamed Niyaz

Daniel Knueppel

Yan Hao

Nicholas R Babij

Sarah Ryan

Satoshi Tsuchiya

Michael Thomas Sullenberger

Takashi Emura

David Michael Remick

Radhe Krishan Vaid

Mark Steven Kerr

Manabu Wadamoto

Molly Hess

Adriana Jemison

Derek Robert Starkey

Kenneth Derek Berglund

Ayman D Allian

Audrey Grace Mack

Ashlee Jeanette Davis

Fumiki Kawagishi

Minoru Yamawaki

Jerod Patzner

Kevin Paul Cole

Xavier A Ortiz-medina

Carl Deamicis

The present invention relates to the synthesis of 3-[(1S,2S)-1-[5-[(4S)-2,2-dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl ]-4-methyl-6,7-dihydro-4H-pyrazolo [4,3-c] pyridine-5-carbonyl] indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one, or a salt thereof, and related synthetic intermediate compounds.

Process to make GLP1 RA and intermediates therefor

Provided herein is a process for the preparation of 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-mercapto-1H-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile.

4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-mercapto-1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation

Provided herein is a process for the preparation of 4-((6-bromopyridin-3-yl)oxy)benzonitrile.

4-((6-bromopyridin-3-yl)oxy)benzonitrile and processes of preparation

Provided herein is a process for the preparation of 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile.

4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)pyridin-3-yl and processes of preparation

The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.

Processes for the preparation of pesticidal compounds

3-(3-Chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine.dihydrochloride with commercially available 3-ethoxyacrylonitrile to provide 3-(3-amino-1H-pyrazol-1-yl)pyridine, and by converting the amino group to a chloro group by a Sandmeyer reaction.

Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine

3-(3-chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-.dihydrochloride with a dialkyl maleate to provide an alkyl 5-oxo-2-(pyridin-3-yl)pyrazolidine-3-carboxylate, by chlorinating to provide an alkyl 3-chloro-1-(pyridin-3-yl)-4,5-dihydro-1H-pyrazole-5-carboxylate, by oxidizing to provide an alkyl 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylate, by converting the ester to the carboxylic acid by hydrolysis to provide 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylic acid hydrochloride, and by removing the carboxylic acid by a decarboxylation reaction.

Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine

This disclosure relates to the field of preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine and intermediates therefrom. These intermediates are useful in the preparation of certain pesticides.

Process for the preparation of 3-(3-CHLORO-1H-pyrazol-1-yl)pyridine

3-(3-Chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-dihydrochloride with commercially available 3-ethoxyacrylonitrile to provide 3-(3-amino-1H-pyrazol-1-yl)pyridine, and by converting the amino group to a chloro group by a Sandmeyer reaction.

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3-(3-chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-&#x2022;dihydrochloride with a dialkyl maleate to provide an alkyl 5-oxo-2-(pyridin-3-yl)pyrazolidine-3-carboxylate, by chlorinating to provide an alkyl 3-chloro-1-(pyridin-3-yl)-4,5-dihydro-1H-pyrazole-5-carboxylate, by oxidizing to provide an alkyl 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylate, by converting the ester to the carboxylic acid by hydrolysis to provide 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-5-carboxylic acid hydrochloride, and by removing the carboxylic acid by a decarboxylation reaction.

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Zionsville, IN, United States of America

Qiang Yang