Hubei Bio-pharmaceutical Industrial Technological Institute Inc.

Humanwell Healthcare (group) Co., Ltd.

Wuhan Optics Valley Humanwell Bio-pharmaceutical Co., Ltd.

Hubei Biological Medicine Industrial Technology Institute Co., Ltd.

Wuhan Chemligand Bio-pharmaceutical Co., Ltd.

Humanwell Healthcare Co., Ltd.

Qiang Xiao

Yong Xu

Lu Huang

Xuehai Wang

Zhongwen Yang

Ronghua Tu

Yang Yue

Jing Yang

Hua Tian

Yanping Yu

Li'e Li

Guoping Hu

Chengde Wu

Yi Zhang

Chunli Shen

Jian Li

Wenjie Sun

Hailiang Chen

Jie Shen

Jie Li

Wen Zhou

Gang Chen

Jing Tang

Nengyang Shi

Zhenyu He

Xijun Sheng

Shuhui Chen

Xiaolin Zhang

Tianci Huang

Chengbing Yang

Zhaoze Fan

Yun Feng

Rubin Cao

Hangui Xia

Quan Liu

Jing Yu

Diliang Guo

Xuwen Zhang

The present invention provides a pyrimidine derivative and a use thereof. The pyrimidine derivative is the compound shown in formula I or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein, R, R, R, Rand Rare, for example, as defined in the specification. The compound can act as an ALK inhibitor, and is for preparing an anti-tumor medicament for suppressing an anaplastic lymphoma kinase. 

Pyrimidine derivative and use thereof

Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV). 

BTK inhibitor

A capsule containing total flavonoids of, a method for preparing the same and a use of the capsule containing total flavonoids ofare provided. Specifically, the capsule includes total flavonoids ofprovided in a form of alcohol extract ofand a pharmaceutically acceptable excipient.

Capsule containing total flavonoids of desmodium styracifolium, method for preparing the same and use

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Wuhan, China

Qiang Xiao