Hubei Bio-pharmaceutical Industrial Technological Institute Inc.

Humanwell Healthcare (group) Co., Ltd.

Wuhan Optics Valley Humanwell Bio-pharmaceutical Co., Ltd.

Hubei Biological Medicine Industrial Technology Institute Co., Ltd.

Wuhan Chemligand Bio-pharmaceutical Co., Ltd.

Humanwell Healthcare Co., Ltd.

Qiang Xiao

Yong Xu

Lu Huang

Xuehai Wang

Zhongwen Yang

Ronghua Tu

Jing Yang

Yang Yue

Hua Tian

Li'e Li

Yanping Yu

Guoping Hu

Chengde Wu

Yi Zhang

Jian Li

Chunli Shen

Hailiang Chen

Jie Shen

Wenjie Sun

Wen Zhou

Jie Li

Nengyang Shi

Jing Tang

Gang Chen

Chengbing Yang

Diliang Guo

Tianci Huang

Shuhui Chen

Xuwen Zhang

Zhaoze Fan

Xijun Sheng

Xiaolin Zhang

Zhenyu He

Hangui Xia

Jing Yu

Quan Liu

Rubin Cao

Yun Feng

The present invention provides a pyrimidine derivative and a use thereof. The pyrimidine derivative is the compound shown in formula I or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein, R, R, R, Rand Rare, for example, as defined in the specification. The compound can act as an ALK inhibitor, and is for preparing an anti-tumor medicament for suppressing an anaplastic lymphoma kinase. 

Pyrimidine derivative and use thereof

Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV). 

BTK inhibitor

A capsule containing total flavonoids of, a method for preparing the same and a use of the capsule containing total flavonoids ofare provided. Specifically, the capsule includes total flavonoids ofprovided in a form of alcohol extract ofand a pharmaceutically acceptable excipient.

Capsule containing total flavonoids of desmodium styracifolium, method for preparing the same and use

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Wuhan, China

Qiang Xiao