Cisdi Engineering Co., Ltd

Chongqing Pharmaceutical Research Institute Co., Ltd

Yaopharma Co., Ltd.

Cisdi Research and Development Co., Ltd.

Qiang Liu

Xiaoqing Bai

Zhiwei Han

Xiang Li

Yaming Cao

Wei Nie

Yiwen Kong

Xiaolong Kerri Yan

Bitao Deng

Haoying Xu

Zhichao Xu

Hongkun Qin

Hongyi Liu

The present disclosure relates to a GLP-1R agonist compound and use thereof, and specifically provides a compound represented by Formula I, or an isotope-labelled compound, a stereoisomer, or a pharmaceutically acceptable salt thereof, and use thereof as a medicament. The compound exhibits excellent agonistic effects and pharmacodynamic properties on GLP-1R and, as a modulator, is useful for manufacturing a medicament for the treatment, amelioration, or prevention of metabolic diseases and related diseases, thus having broad application prospects.

GLP-1R agonist compound and use thereof

A process for thin strip production integrates continuous casting and rolling, with steps including continuous casting, rough rolling, induction heating, finish rolling, laminar cooling, high-speed shearing, and coiling. A key feature is the in-line heating between casting and rough rolling, where wide surfaces, narrow surfaces, and corners of the casting blank are heated simultaneously. This process improves rough rolling efficiency, enhances uniformity and thickness stability of thin strips, reduces out-of-tolerance rates, and minimizes rolling-induced cracks.

Thin strip production process employing continuous casting and rolling

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Chongqing, China

Qiang Liu