W. L. Gore & Associates, Inc.

Viacyte, Inc.

Qiang (John) Zhang

Kevin Allen D'Amour

Michael J Scott

Laura A Martinson

Christopher R Folk

Greg Rusch

Craig McGreevy

Lauren Zambotti

Scott A Ritrovato

Timothy M Bruhn

Joseph Kakkassery

A biocompatible membrane composite including a cell impermeable layer and a mitigation layer is provided. The cell impermeable layer is impervious to vascular ingrowth and prevents cellular contact from the host. Additionally, the mitigation layer includes solid features. In at least one embodiment, mitigation layer has therein bonded solid features. In some embodiments, the cell impermeable layer and the mitigation layer are intimately bonded or otherwise connected to each other to form a composite layer having a tight/open structure. A reinforcing component may optionally be positioned external to or within the biocompatible membrane composite to provide support to and prevent distortion. The biocompatible membrane composite may be used in or to form a device for encapsulating biological entities, including, but not limited to, pancreatic lineage type cells such as pancreatic progenitors.

Biocompatible membrane composite

Growing community of inventors

San Diego, CA, United States of America

Qiang (John) Zhang