Jiangnan University

Wuxi Institute of Technology

Qiang Ding

Xiulai Chen

Liming Liu

Jia Liu

Cong Gao

Liang Guo

Jun Wang

Ping Cui

Guipeng Hu

Huabin Mei

Chengming Rao

Conggui Huang

Ming Jiang

The present invention relates to a recombinant strain for producing shikimic acid, in which a target gene that regulates the asymmetric cell division and target genes that regulate the shikimic acid production are expressed The target gene that regulates the asymmetric cell division includes cytoskeletal protein PopZ coding gene popZ, and the target genes that regulate the shikimic acid production include DAHP synthase coding gene aroG, 3-dehydroquinate synthase coding gene aroB, and transketolase coding gene tktA. The recombinant strain of the present invention realizes the de novo synthesis of shikimic acid using glucose as a substrate, with a low cost. After fermentation with the strain in a 7.5 L fermentor, the highest production of shikimic acid is 88.1 g/L, the yield is 0.33 g/g, and the production intensity of shikimic acid is 1.1 g/L/h.

Recombinant strain for producing shikimic acid, and construction method and use thereof

A medical dental grinding apparatus comprises an apparatus body, wherein an air pipeline, a clamping mechanism, and a grinding mechanism are provided in the apparatus body; the air pipeline includes an air inlet pipeline, an air outlet pipeline, and a U-shaped connection pipeline; a silencer is connected to an upper port of the air outlet pipeline; a plane where the air pipeline is located is perpendicular to a plane where the clamping mechanism is located, and the grinding mechanism is provided below the air pipeline; the grinding mechanism is driven by high-pressure air in the air pipeline to operate, so that a hidden danger of electric leakage caused by using an electric apparatus in a fragile oral environment is avoided; and a steel wire is fixed by the clamping mechanism, so that the grinding safety is ensured.

Medical dental grinding apparatus

Growing community of inventors

Wuxi, China

Qiang Ding