Janssen Biotech, Inc.

Qiang Chen

Jinquan Luo

Ann Lacombe

Debra Gardner

Yevgeniya Orlovsky

Karen Duffy

Damon Hamel

Ravi Malaviya

Deepti Wilkinson

Pejman Soroosh

Melissa Swiecki

Shannon Hitchcock

Yanxia Guo

Suzanne Cole

David M Knight

Raymond W Sweet

Ellen Chi

Juan C Almagro

John Wheeler

Wilson Edwards

Ping Tsui

Mark Tornetta

Jin Lu

Brian Whitaker

Paul H Kim

Matt Husovsky

H Mimi Zhou

Lei Shi

Lionella Borozdina-Birch

Ramachandra Reddy

Zemeda Ainekulu

Quynh Nguyen

In certain aspects, the disclosure relates to anti-idiotype antibodies and antigen-binding portions thereof that specifically bind a KL2B413 containing protein, e.g., an antibody or antigen-binding portions thereof. In some aspects, the anti-idiotype antibodies and antigen-binding portions of the present disclosure can be used in methods to detect and quantify cells expressing chimeric antigen receptors that include KL2B413.

Anti-idiotypic antibodies against anti-KLK2 antibodies

Antibodies that specifically bind PD-1 or antigen binding fragments thereof, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing are useful in the treatment of an inflammatory or immune disorder.

Antibodies that specifically bind PD-1 and methods of use

Described and claimed herein are combinatorial synthetic Fab libraries displayed on a phage pIX protein. The libraries were built on scaffolds representing the most frequently used genes in human antibodies, which were diversified to mirror the variability of natural antibodies. After selection using a diverse panel of proteins, numerous specific and high-affinity Fabs were isolated. By a process called in-line maturation the affinity of some antibodies was improved up to one hundred-fold yielding low pM binders suitable for in vivo use. This work thus demonstrates the feasibility of displaying complex Fab libraries as pIX-fusion proteins for antibody discovery and lays the foundations for studies on the structure-function relationship of antibodies.

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Qiang Chen