Medical University of South Carolina

Integrated Micro-chromatography Systems, Inc.

Qian Wang

Zhongwei Niu

Lim Andrew Lee

Charlene M Mello

Kai Li

Krishnamoorthy Sivakumar

Pongkwan Sitasuwan

Gary Horvath

Margarita Marinova

Jun Hu

Siqi Li

L Andrew Lee

Jia Yang

A polymer-protein core-shell nanoparticle is generally provided. In one embodiment, the polymer-protein core-shell nanoparticle includes a pyridinyl group grafted polymer assembled with a protein or a glycoprotein based antigen to form a core-shell particle. A method is also generally provided for treating an infected organism. In one embodiment, the method includes administering the polymer-protein core-shell nanoparticle to the infected organism.

Polymer-protein core-shell particles as effective vaccine delivery vehicles and treatments methods using the same

Methods are generally disclosed for attaching a cell binding motif to a carboxy end of a coat protein of a Tobacco Mosaic Virus particle to form a modified-TMV particle; and attaching a cell to the cell binding motif of the modified-TMV particle. Methods are also disclosed for incorporated virus particles, e.g., TMV virus particles into hydrogels.

Incorporation of plant virus particles and polymers as 2D and 3D scaffolds to manipulate cellular behaviors

A dressing for wound healing is provided, wherein the dressing includes a hydrogen sulfide (HS) donor compound. The dressing facilitates the delivery of HS to a wound site in a controlled manner, which results in an improved wound healing process by stimulating angiogenesis and anti-inflammatory action. In some embodiments, the wound dressing can include an electrospun nanofiber dressing, a sponge dressing, or a hydrogel dressing.

Hydrogen sulfide (H2S) releasing donor compound for dermal wound regeneration

The use of biomaterials, such as viruses and virus-like particles, to form nanostructures is generally disclosed. For instance, rod-like viruses can be used to form composite nanofibers that are fixed together in a head-to-tail assembly by a polymer. Also, 2-dimensional nanostructures formed from crosslinked viruses assembled in a single, film-like layer are generally disclosed. Porous gels having controllable pore size through the use of virus particles are also disclosed.

Bionanomaterials and their synthesis

Mutatedstrain 269Y &#x3b2;-glucuronidase enzymes with enhanced enzymatic activity at low pH (e.g., below pH 6.8), as well as enhanced thermostability as compared to wild type enzyme are provided. The enzymes of the invention advantageously allow for accurate analysis of bodily samples for the presence of drugs at low pH and in 30 minutes or less, as compared to the several hours needed using prior enzyme preparations. Methods of using the mutated enzymes for hydrolysis of glucuronide substrates, including opiates and benzodiazepines, are also provided.

Mutant lactobacillus beta-glucuronidase enzymes with enhanced enzymatic activity

Reactive and modified M13 bacteriophages, and methods of making and using the same, are generally provided. The reactive M13 bacteriophage can include a alkyne functional group covalently attached to the M13 bacteriophage. The modified M13 bacteriophage can include a substituent covalently attached to the M13 bacteriophage via a 1,2,3-triazole linkage. Dual-modified M13 bacteriophages are also generally provided, and can include a cancer-targeting substituent covalently attached to the M13 bacteriophage and a fluorescent group covalently attached to the M13 bacteriophage. The modified M13 bacteriophages can not only be employed as a fluorescent probe for cancer imaging, but also can be used as biomaterials for cell alignment and scaffolding.

M13 bacteriophage as a chemoaddressable nanoparticle for biological and medical applications

Methods are provided for forming a xanthone derivative via reacting a 2-substituted benzaldehyde with a phenol derivative to form the xanthone derivative.

Methodology for the synthesis of xanthones

A polymeric sensing fluid for detecting the presence of glucose and systems and methods of its use are generally disclosed. The polymeric sensing fluid includes a polymer in a solvent (e.g., an aqueous solvent). The polymer has a plurality of boronic acid moieties extending from its polymeric backbone. As such, the polymeric sensing fluid is configured to increase in viscosity upon addition of glucose due to crosslinking between the boronic acid moieties of the polymer and glucose.

Glucose monitoring by viscometric sensing of polymeric fluid

The present invention describes a bioconjugation strategy and compounds that are useful therein in which a fluorescent signal is produced when two molecular or supramolecular entities are linked by chemoselective combination of one linker having an azido or halide substituent group with another linker having a cyano or an alkyne substituent group. A kit is also provided.

Growing community of inventors

Columbia, SC, United States of America

Qian Wang