Chinese Academy of Sciences

Shanghai Meiyue Biotech Development Co., Ltd.

Qian He

Jing Li

Jian Ding

Yi Chen

Yan Feng

Lu Zhang

Xi Zhang

Chaodong Wang

Xiang Wang

Linghua Meng

Chunhao Yang

Cun Tan

Xiaolin Wang

Shanghai Yu

Zhilong Hu

Yuehu Wang

Jifeng Luo

Shuya Wei

Mengyuan Xia

Haoyue Xiang

Yawen Ding

Shiqiang Li

Feihong Dai

Guozhong Ye

Chenli Ding

(5R,7R,10R)-12,15-dioxo-α-selinene (PFC-37) is used in the preparation of a drug for preventing and treating a neurodegenerative disease and Parkinson's disease.

Use of (5R,7R,10R)-12,15-dioxo-α-selinene in the preparation of drugs

A quaternary lactam compound of formula (I). The compound is used in the manufacture of a medicament for the treatment and/or prevention of thrombotic or thromboembolic disorders. 

Quaternary lactam compound and pharmaceutical use thereof

The present disclosure relates to 7-substituted pyrrolo[2,1-f][1,2,4]triazine compounds or pharmaceutically acceptable salts thereof, and preparation methods and uses thereof. These compounds show good PI3K inhibitory activity, can effectively inhibit the activity of PI3K kinase, and has significant enhancement and improvement of pharmacokinetic properties, such as bioavailability, due to the introduction of the 7-position group; furthermore, the compounds of the present disclosure exhibit an unpredictable high selectivity and strong inhibitory activity on PI3K&#x3b4;, and thus these compounds can be used for treating diseases related to PI3K pathway, especially for anti-cancer or for the treatment of tumors, leukemias and autoimmune diseases. After further optimizing and screening, the compounds are expected to be developed into a new type of anti-tumor drugs.

7-site substituted pyrrole triazine compounds or pharmaceutically acceptable salts thereof, and preparation method thereof and uses thereof

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Shanghai, China

Qian He