Rhode Island Hospital

Brown University

National Research Council of Canada

The Governors of the University of Alberta

Qian Chen

Yupeng Chen

Hongchuan Yu

Michael G Ehrlich

Thomas J Webster

Hicham Fenniri

Usha Devi Hemraz

Chathuraka T Jayasuriya

John M Sedivy

Richard M Terek

Marco De Cecco

Yunpeng Chen

Xiaojuan Sun

Yun Gao

The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.

Nanocarriers and their processing for diagnostics and therapeutics

Described herein is are compositions and methods for treating an articulating joint disorders, comprising systemically administering to a subject a nucleoside reverse transcriptase inhibitor (NRTI).

Composition and methods for treating articulating joint disorders with nucleoside reverse transcriptase inhibitors

In vitro and in vivo intracellular delivery of siRNA via self-assembled nanopieces

This invention is directed to, inter alia, stable cartilage-derived progenitor cell lines as well as methods for producing stable cartilage-derived progenitor cell lines from diseased human cartilaginous tissues and lesions. Also provided herein are methods for using cartilage-derived progenitor cell lines for treatment of cartilage and bone degenerative diseases.

Cartilage-derived mesenchymal cell lines

Compositions or an assembly of a series of biomimetic compounds include chemical structures that mimic or structurally resemble a nucleic acid base pair. Complexes of nanotubes and agents are useful to deliver agents into the cells or bodily tissues of individuals for therapeutic and diagnostic purposes. Exemplary compounds include those of Formula (I), (III), (V) or (VII), or of Formula (II), (IV), (VI) or (VIII). 

Nanomaterial compositions, synthesis, and assembly

This invention is directed to, inter alia, compositions and methods for restoring normal microRNA (miR) expression in chondrosarcoma cells as well as methods for treating and diagnosing chondrosarcoma in individuals in need thereof.

Methods for treating chondrosarcoma using microrna(miR)

The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids.

Nanotubes as carriers of nucleic acids into cells

Methods for reducing the severity of an arthritic condition or repairing an osteochondral defect are carried out by administering to a subject compositions comprising a member of the matrilin family of proteins, e.g., a matrilin protein, fragment thereof, or nucleic acid encoding the protein or fragment.

Growing community of inventors

Barrington, RI, United States of America

Qian Chen