Other

Liangdan Sun

Sun, Liangdan

Qi Zhen

Weiwei Chen

Yirui Wang

Zhuo Hua Li

Bao Li

Zhuo Li

Liang Yong

An application of CaMK4 as a target in preparation of medicines for preventing and treating psoriasis and an application of a CaMK4 inhibitor in preparation of medicines for preventing and treating psoriasis are provided. The expressions of CaMK4 in skin lesions of patients with psoriasis and IMQ induced skin lesions of mice with psoriasis are detected, and the results show that CaMK4 is positively correlated with psoriasis development. CaMK4 is expressed not only in immune cells, but also in keratinocytes. Moreover, IL-10 and the CaMK4 inhibitor can reduce psoriasiform inflammation induced by IMQ in mice. It shows that CaMK4 can be used as a new target in the preparation of medicines for prevention and treatment of psoriasis.

Application of CaMK4 in preparation of medicine for preventing and treating psoriasis

A use of a compound or a medicinal derivative thereof in inhibiting absent in melanoma 2 (AIM2) protein activity is provided and belongs to the field of protein inhibitory medicines. Compared with traditional broad-spectrum immunomodulators, the compound has a strong targeting effect, and is more accurate, rapid, effective, safe and stable. Moreover, the compound has a strong binding force with human AIM2 protein and mouse AIM2 protein, and binding constants are as high as K=1.56EM and K=5.12EM respectively. Compared with traditional biological inhibitors, the compound has advantages of easy storage, stable activity, small molecular weight, lower production cost and easy absorption.

Use of compound or medicinal derivative thereof in inhibiting AIM2 protein activity

A use of a compound or a medicinal derivative thereof in inhibiting calcium/calmodulin-dependent protein kinase type II gamma (CaMK2γ) protein activity is provided, and belongs to the technical field of protein inhibitors. Compared with traditional broad-spectrum immunomodulators, the compound has a strong targeting effect, and is more accurate, rapid, effective, safe, and stable. Moreover, the compound has a strong binding force with human-derived CaMK2γ protein and mouse-derived CaMK2γ protein, and binding constants are KD=2.54×10M and KD=6.84×10M respectively. Compared with traditional biological inhibitors, the compound has advantages of easy storage, stable activity, small molecular weight, lower production cost and easy absorption.

Use of compound or pharmaceutical derivative thereof in inhibiting CaMK2G protein activity

A use of a compound or a medicinal derivative thereof in inhibiting absent in melanoma 2 (AIM2) protein activity is provided, and belongs to the field of protein inhibitory medicine technology. Compared with traditional broad-spectrum immunomodulators, the compound has a strong targeting effect, and is more accurate, rapid, effective, safe and stable. Moreover, the compound has a strong binding force with human AIM2 protein and mouse AIM2 protein, and binding constants are as high as 1.029E-5M and 1.033E-5M respectively. Compared with traditional biological inhibitors, the compound has advantages of easy storage, stable activity, small molecular weight, lower production cost and easy absorption.

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Hefei, China

Qi Zhen