Universitetet I Oslo

Other

Universite Claude Bernard – Lyon1

Ge Healthcare As

Amersham Health As

Bergen Teknologioverføring As

Drug Discovery Laboratory As

Universitetet | Oslo

Adjutec Pharma As

Golden Omega Norway As

Pål Rongved

Ove Alexander Høgmoen Åstrand

Geir Kildahl-Andersen

Jo Klaveness

Ørjan Samuelsen

Ole Andreas Løchen Økstad

Elvar Ørn Viktorsson

Christian Schnaars

Ørjan Samuelson

Adam Heikal

Edward R Bacon

John L Toner

Morten Eriksen

Gregory L McIntire

Harald Dugstad

Sigmund Frigstad

Paul Mark Henrichs

Roald Skurtveit

Audun Tornes

Edvin Wilhelm Johannesen

Vinay Chandrakant Desai

Wolfgang Hans Heinrich Gunther

Annette Bayer

Stein Ove Døskeland

Lars Herfindal

Marc Le Borgne

Elvar Örn Viktorsson

Øyvind Jacobsen

David Johnson

Jonny Østensen

Hanna-Kirsti Schrøder Leiros

Jorunn Brænden

Kine Susann Waade Edvardsen

Bjarne Brudeli

Zeeshan Muhammad

Bjorn Fuglaas

Ove Alexander Høgmoen ÅStrand

A combination product comprising a carbapenem and a compound of formula (I′), or a pharmaceutically acceptable salt thereof: a pharmaceutical composition comprising the combination product; and methods of treating bacterial or fungal infections using the combination product and pharmaceutical composition.

Substituted phenazines and methods of treating cancer and bacterial diseases

The invention provides compounds for use in a method of treating and/or preventing a bacterial infection in a human or non-human mammal, said method comprising administration of said compound in combination with (either simultaneously, separately, or sequentially) a &#x3b2;-lactam antibiotic, wherein said compound has the general formula I: (wherein:

Compounds

Compounds of formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds.

The invention provides compounds for use in a method of treating and/or preventing a bacterial infection in a human or non-human mammal, said method comprising administration of said compound in combination with (either simultaneously, separately, or sequentially) a &#x3b2;-lactam antibiotic, wherein said compound has the general formula I: (I) (wherein: Q is a lipophilic, zinc chelating moiety which is selective for Znions and which comprises at least one, preferably two or more (e.g 2, 3 or 4), optionally substituted, unsaturated heterocyclic rings, e.g. 5 or 6-membered heterocyclic rings (such rings preferably include at least one heteroatom selected from N, S and O, preferably N); wherein any optional substituents may be selected from Calkyl, Calkoxy, halogen, nitro, cyano, amine, and substituted amine; each L, which may be the same or different, is a covalent bond or a linker; each W, which may be the same or different, is a non-peptidic hydrophilic group which comprises one or more hydroxy groups; and x is an integer from 1 to 3) or a stereoisomer, pharmaceutically acceptable salt or prodrug thereof.

Compounds according to formula I are provided:A-L-Bwherein A represents a lipophilic chelating moiety which is selective for Znions; L is a covalent bond or a linker; and B is a vector which is either a moiety capable of interacting with one or more biological structures found in a bacterium (preferably in a bacterial cell wall), for example a penicillin-binding protein such as a metallo-&#x3b2;-lactamase or DD-transferase, or a moiety capable of enhancing transport of the compound across a bacterial cell membrane. A method of treating and/or preventing a bacterial infection in a human or non-human mammal employing such compounds are also provided. In such a method, the compound of formula I may be administered in combination with (either simultaneously, separately, or sequentially) a &#x3b2;-lactam antibiotic.

Inhibitors of metallo-beta-lactamase (MBL) comprising a zinc chelating moiety

Novel phenazine derivatives, methods for their preparation and their medical use, in particular as anti-neoplastic agents and anti-infective agents, are provided. Novel methods for the preparation of iodinin and myxin are also provided.

Phenazine derivatives as anti-neoplastic agents and anti-infective agents

A peptide which can adopt a 3-helical conformation in which the side chains of two amino acid residues in the peptide backbone are linked by a group comprising an aromatic 5-membered ring.

Peptides

Ultrasound contrast agents comprising microbubbles of biocompatible gas, e.g. a sulphur halide or a perfluorocarbon, stabilized by opsonisable amphiphilic material, e.g. a membrane-forming lipid such as a phospholipid, especially a negatively charged phospholipid such as a phosphatidylserine, may exhibit prolonged contrast-generating residence time in the liver following intravenous administration.

Contrast agents

The present invention relates to the use of particulate materials as contrast agents in in vivo light imaging.

Light imaging contrast agents

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Oslo, Norway

Pål Rongved