E. R. Squibb Sons, Inc.

Pushpa Singh

Richard B Sykes

William L Parker

Joseph O'Sullivan

Wen-Chih Liu

Carol A Aklonis

Dorothy S Slusarchyk

Karen Bush

William Lawrence Parker

Richard Brook Sykes

4-Diazo-3-methoxy-2,5-cyclohexandien-1-one, and pharmaceutically acceptable salts thereof, are antibiotics having antibacterial activity against a variety of gram positive and gram negative bacteria, particularly against anaerobic bacteria. The compound can be prepared by culturing aerobically Penicillium funiculosum A.T.C.C. No. 20783 in a culture medium containing assimilable sources of carbohydrates and nitrogen.

4-diazo-3-methyl-2,5-cyclohexadine-1-one and pharmacetically acceptable

Aerocavin, a novel antibiotic substance having the structure ##STR1## and aerocyanidin, a novel antibiotic substance having the structure ##STR2## can be prepared by cultivation of the microorganism Aerocavin caviae SC 14,030 A.T.C.C. No. 53434.

Aerocyanidin-antibiotic

Aerocavin antibiotics

Plastatin, an inhibitor of the enzyme phospholipase A.sub.2, can be prepared by cultivating Penicillium chermesinum under submerged aerobic conditions.

Plastatin

N.sup.2 -[N-(N-acetylmuramoyl)-L-alanyl]-N-(5,6-diamino-1-carboxy-6-oxohexyl)-D-.a lpha.-glutamine, N.sup.2 -[N-(N-acetylmuramoyl)-L-alanyl]-N-[5,6-diamino-1-[[1-[(1-carboxyethyl)car bamoyl]ethyl]carbamoyl]-6-oxohexyl]-D-.alpha.-glutamine and EM5556C are obtained as a mixture by cultivating a strain of the microorganism Nocardia orientalis A.T.C.C. No. 39444.

ACE inhibitors produced from Nocardia orientalis

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Piscataway, NJ, United States of America

Pushpa Singh