Matrix Laboratories Limited

Purna Chandra Ray

Madhuresh Kumar Sethi

Seeta Ramanjaneyulu Gorantla

Om Dutt Tyagi

Gorantla Seeta Ramanjaneyulu

Vemula Lakshminarayana

Mamidi Srinivas

Bandari Mohan

Jagan Mohana Chary Tummanapalli

Bhausaheb Chavhan

Vijendra Singh Rawat

Yerramalla Raja Krishna

Sreekanth Medikonduri

The present invention relates to a process for the preparation of pure Rabeprazole sulfoxide using the solvent mixture for the extraction steps and this invention further relates to the process for the preparation of amorphous Rabeprazole sodium using pure rabeprazole base in presence of aqueous NaOH and water miscible solvent and adding an anti-solvent.

Process for the preparation of pure rabeprazole

The present invention provides a process for the preparation of Olmesartan medoxomil by condensing the ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate with 4-[2-(trityl tetrazol-5-yl)phenyl]benzyl bromide to obtain ethyl 4-(1-hydroxy-1-methyl ethyl)-2-propyl-1-{4-[2-(trityl tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate and then hydrolyzing ethyl 4-(1-hydroxy-1-methyl ethyl)-2-propyl-1-{4-[2-(trityl tetrazol-5-yl)phenyl]phenyl}methyl imidazole-5-carboxylate to obtain trityl Olmesartan dihydrate followed by reacting trityl Olmesartan dihydrate with 4-chloromethyl-5-methyl-2-oxo-1,3-dioxolene to obtain trityl Olmesartan medoxomil and then deprotecting trityl Olmesartan medoxomil to obtain Olmesartan medoxomil.

Process for the preparation of olmesartan medoxomil

The present invention provides a method for preparing pure Stavudine having purity more than 99.5% comprises: i) Converting 3',5&#x2032;-anhydrothymidine to crude Stavudine, ii) Converting crude Stavudine to stable solvates of Stavudine, iii) Desolvation of the solvates to give pure Stavudine. The present invention also disclosed novel solvates of Stavudine and conversion of novel Stavudine solvates to Stavudine.

Process for the large scale production of Stavudine

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Hyderabad Telangana, India

Purna Chandra Ray