St. Elizabeth's Medical Center of Boston, Inc.

St. Elizabeth's Medical Center

Pura J Requintina

Gregory F Oxenkrug

Sergei O Bachurin

Andrey Zakharovic Afanasiev

This invention relates to the use of N-acetyl-serotonin (NAS) derivatives for the treatment and prophylaxis of neurological injury and neurodegenerative disorders in a mammal.

Method of treating neurodegenerative disorders

The present invention relates to a method of treatment of hypertension in a mammal, particularly a human being. This method comprises the administration of a therapeutically effective hypertension treatment amount of N-acetylserotonin (NAS) to the mammal.

Method for treating hypertension

The present invention relates to a method of treatment of depression in a human being identified as having depression. This method comprises the administration of a therapeutically effective depression treatment amount of N-acetyl-serotonin (NAS), also referred to as N-acetyl-5-hydroxytryptamine, to a human being identified as having depression. The NAS may be administered alone or in combination with other agents, e.g., Ca.sup.++ antagonists.

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West Kingston, RI, United States of America

Pura J Requintina