Millennium Pharmaceuticals Limited

Millenium Pharmaceuticals, Inc.

Punna Sreenivas

Mukund Shankar Chorghade

Mukund Keshao Gurjar

Susanta Sekhar Adhikari

Sunil Vyankatesh Mhaskar

Gangavaram Vasantha Madhava Sharma

Alla Venkata Rama Rao

Tangallapally Rajendra Prasad

Vavilala Goverdhan Reddy

Sista Venkata Sai Lalitha

Andappan Murugaiah Subbaiah Murugaiah

Aminul Islam

Chittineni Hari Prasad

Palakodety Radha Krishna

Kashinath Sadalapure

Batchu Venkateswara Rao

Levadala Murali Krishna

Bethi Sridhar Reddy

Hymavathi Lanka

The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetrahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.

Substituted oxygen alicyclic compounds, including methods for synthesis thereof

The invention includes inter alia new methods for preparation of the pharmaceutically active compound 2-(4-fluorophenoxymethyl)-5-(4-N-hydroxyureidyl-1 -butynyl)-tetrahydrofuran and precursors thereof.

Methods of synthesis of substituted tetrahydrofuran compound

The invention includes inter alia new methods for preparation of the pharmaceutically active compound 2-(4-fluorophenoxymethyl)-5-(4-N-hydroxyureidyl-1-butynyl)-tetrahydrofuran and precursors thereof.

Methods for synthesis of substituted tetrahydrofuran compound

The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.

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Nalgonda, India

Punna Sreenivas