Merck Sharp + Dohme Corp.

Puneet Kumar

Amjad Ali

Joseph Leslie Duffy

Andrew William Stamford

Scott D Edmondson

Dong-Ming Shen

Younong Yu

Ying-Duo Gao

John S Debenham

Cheng Zhu

Zhuyan Guo

Rongze Kuang

Santhosh Francis Neelamkavil

Rajan Anand

Yeon-Hee Lim

Yu Jiang

Weiguo Liu

Jiayi Xu

Nancy J Kevin

Heping Wu

Deyou Sha

Meng Yang

Zahid Hussain

Remond Moningka

Anjan Chakrabarti

Gioconda V Gallo-Etienne

Hiroki Sone

Joseph L Duffy

Andrew M Stamford

The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

Factor XIa inhibitors

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more compounds of Formula (I), and methods for using the compounds of Formula (I) for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

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Edison, NJ, United States of America

Puneet Kumar