University of Pennsylvania

Sidra Medicine

Puneet Bagga

Ravinder Reddy

Hari Hariharan

Mitchell D Schnall

Ravi Prakash Reddy Nanga

Catherine DeBrosse

Mohammad Haris

Francesco M Marincola

The present disclosure relates to magnetic resonance imaging (MRI) methods comprising (i) obtaining a baseline chemical exchange saturation transfer (CEST) MRI image of a patient, (ii) administering an effective amount of a non-nutritive sweetener to the patient, and (iii) obtaining one or more test CEST MRI image of the patient subsequent to the administering step (ii); wherein the step (i) and (iii) acquisition parameters are substantially the same. The non-nutritive sweetener may include a natural or artificial sugar alcohol, polyol, or combinations or derivatives thereof.

Non-nutritive sweeteners and polyols as imaging agents

CEST imaging technique and MR scanning are used as an MRI method for detecting levels of lactate in vivo by exploiting the exchange of &#x2014;OH protons on lactate with bulk water. In accordance with this method, one first obtains a lactate CEST MRI map of a slice of the body of a patient. A contrast agent such as pyruvate, glucose or glutamine is administered and a post-administration CEST MRI map is obtained. The difference in the spatial maps indicates the level of expression of lactate in the tissue of interest.

Chemical exchange saturation transfer (CEST) imaging of lactate (LATEST)

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Philadelphia, PA, United States of America

Puneet Bagga