Ohio State Innovation Foundation

The University of Oklahoma

Pui Kai Li

Chenglong Li

Robert A Baiocchi

Fengting Yan

Marie H Hanigan

Disclosed herein are compositions and methods for cancer detection and treatment. Compounds that inhibit PRMT5 are contemplated, as are pharmaceutical compositions comprising a therapeutically effective amount of at least one PRMT5 inhibitor. In some embodiments pharmaceutical compositions further comprising at least one HDAC inhibitor are contemplated. Methods of treating disorders in a mammal by inhibiting PRMT5 by administering to a mammal, a therapeutically effective amount of a PRMT5 inhibitor are also disclosed.

Compositions and methods for cancer detection and treatment

Compositions that are effective in inhibiting gamma-glutamyl transpeptidase are disclosed. Methods of producing and using these compositions are also disclosed.

Growing community of inventors

Galloway, OH, United States of America

Pui Kai Li