Rutgers, the State University of New Jersey

Memorial Sloan Kettering Cancer Center

University of Bonn

The Rockefeller University

Pu Gao

Thomas Tuschl

Gunther Hartmann

Roger A Jones

Dinshaw J Patel

Winfried Barchet

Manuel Ascano, Jr

Thomas Zillinger

Barbara L Gaffney

Yizhou Liu

Yang Wu

Liang Deng

Weiyi Wang

Roger Jones

The present disclosure provides, among other things, compounds comprising cyclic dinucleotides containing a 2',5' linkage useful in the design of research tools, as research tools, and as therapeutic modalities such as enzyme modulators.

Compositions and methods for altering second messenger signaling

The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.

The present invention provides STING crystals. The present invention also provides STING modulators that interact with sites present in and/or defined by such crystals. The present invention also provides methods of making and using such crystals and modulators. Other aspects and/or features of the present invention will be apparent to those skilled in the art, reading the present specification.

STING crystals and modulators

The present disclosure provides, among other things, novel cyclic-GMP-AMP (cGAMP) analogs, mimics, mimetics and variants, and compositions and kits thereof; methods of using the compounds as described herein for treating cancer, and immune disease, disorders, or conditions; methods of using the compounds as described herein for modulating cGAS and STING; and methods of designing or characterizing a cGAS modulator.

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Pu Gao