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Prudence Ann Hill

Darren James Kelly

Richard Ernest Gilbert

Steven James Chadban

David John Nikolic-Paterson

Robert Charles Atkins

Mark Emmanuel Cooper

The present invention relates to the use of PDGF receptor tyrosine kinase inhibitors, especially of N-phenyl-2-pyrim-idine-amine derivatives of formula (I), in which the symbols and substituents have the meaning as defined herein in free form or in pharmaceutically acceptable salt form, in the manufacture of a pharmaceutical composition for the treatment of diabetic nephropathy; to a method of treatment of warm-blooded animals, including humans, suffering from diabetic nephropathy; and to the use of a PDGF receptor tyrosine kinase inhibitor of the formula (I), wherein Ris pyridyl bonded at a carbon atom, R, R, R, Rand Rare each hydrogen, Ris lower alkyl, Ra radical of formula (II): &#x2014;N(R)&#x2014;C(&#x2550;X)&#x2014;(Y)&#x2014;R, wherein Rhydrogen, X is oxo, n is 0 and Ris 4-methyl-piperazinyl-methyl, or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for treating glomerulonephritis, chronic pyelonephritis or IgA nephropathy.

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Canterbury, Victoria, Australia

Prudence Ann Hill