Apotex Pharmachem Inc.

Apotex Inc.

Probal Kanti Datta

Allan W Rey

Yajun Zhao

Cameron L McPhail

David A Stradiotto

Lotfi Derdour

Martin Ehlert

Gamini Weeratunga

Stephen E Horne

K S Keshava Murthy

Carlos Zetina-Rocha

Craig Stewart

Ks Keshava Murthy

Michael B Johansen

Matthew Pompili

Krista Lyn Traynor

Stephen E Home

Matthew A Pompili

A solid form of Nilotinib hydrochloride, which exists as a co-crystal of nilotinib hydrochloride and levulinic acid having a molar ratio of nilotinib hydrochloride to levulinic acid of 1:2, and a process for the preparation of the co-crystal.

Solid forms of nilotinib hydrochloride

Disclosed are solid forms of Nilotinib hydrochloride and methods of preparation of various crystalline solvates of Nilotinib HCl including benzyl alcohol, acetic acid, propylene glycol, and isopropanol. Nilotinib HCl is a tyrosine kinase inhibitor used for the treatment of drug resistant chronic myelogenous leukemia (CML).

This invention relates to 1,3-oxathiolane derivatives (I), processes for the preparation of 1,3-oxathiolane derivatives and intermediate compounds thereof. 

1,3-Oxathiolane derivatives, process for the preparation of 1,3-Oxathiolane derivatives and intermediates thereof

A process for the preparation of an acid addition salt of an organic base comprising exposing the organic base in solid form to a gaseous acid, with the proviso that ziprasidone, its acid addition salts and intermediates thereof are excluded.

Preparation of acid addition salts of amine bases by solid phase&#x2014;gas phase reactions

A process for the preparation of an acid addition salt of ziprasidone base and intermediates thereof comprising exposing the ziprasidone base in solid form to a gaseous acid in a substantially dry environment.

Preparation of acid addition salts of ziprasidone and intermediates thereof by solid phase-gas phase reactions

A novel form of Ibandronate sodium which is particularly suitable for pharmaceutical applications, and a process for preparing said novel form.

Ibandronate sodium propylene glycol solvate and processes for the preparation thereof

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Hamilton, Canada

Probal Kanti Datta