The City University of New York

The Feinstein Institutes for Medical Research

Probal Banerjee

Krishnaswami Raja

Wei Shi

William L'Amoreaux

Andrew B Auerbach

Sukanta Dolai

Saadyah Averick

Raja Krishnaswami

Mario R Castellanos

Shawon Debnath

Amit Mogha

Christopher Corbo

Alejandra Alonso

Anita Szerszen

Jimmie E Fata

Krishnaswami S Raja

William L'amoreaux

Priya Ranjan Debata

The invention relates to novel curcumin derivatives in which one or two of the phenolic groups have been modified.

Curcumin derivatives

The invention relates to novel curcumin and tetrahydrocurcumin derivatives, which have been modified at one phenolic group to incorporate more-reactive groups. The curcumin and tetrahydrocurcumin derivatives are in the form of monomers, dimmers, and polymers.Z-L-Y&#x2003;&#x2003;(I)wherein: Z is represented by: 

Curcumin and tetrahydrocurcumin derivatives

The invention relates to curcumin derivatives having the formula I: wherein: Z represents: HCO A represents &#x2014;CH&#x2014;CH&#x2014; or &#x2014;CH&#x2550;CH&#x2014;; L represents &#x2014;C(O)&#x2014;(NH)&#x2014;R&#x2014;(NH)&#x2014;C(O)&#x2014;; R represents a saturated or unsaturated, branched or unbranched hydrocarbyl chain having a minimum of 3 carbon atoms in the chain; wherein the maximum number of carbon atoms in the chain is 24; and wherein the carbon atoms of the chain can be replaced by at least one heteroatom, wherein the heteroatoms are independently &#x2014;O&#x2014; or &#x2014;NH&#x2014;, with the proviso that each heteroatom is separated from each other heteroatom by at least two carbon atoms; n1 and n2 independently represent 0 or 1; and Y represents an antibody that binds specifically to a target antigen of a tumor cell. The invention further relates to methods of method of inhibiting the growth of tumors in a human by administering an effective amount of the curcumin derivative, and to methods of producing the curcumin derivative. 

Curcumin-antibody conjugates as anti-cancer agents

Water soluble polymers having formula I: Y-(L)-(C(O))&#x2014;(R)&#x2014;Rare claimed. The polymers may contain multiple water soluble, immunogenicity reducing moieties and multiple active moieties. The polymers may be linked to a protein, or a peptide having up to twelve amino acids.

Living copolymer-protein/peptide hybrids for biomedical applications

The invention relates to novel curcumin and tetrahydrocurcumin derivatives, which have been modified at one phenolic group to incorporate more-reactive groups. The curcumin and tetrahydrocurcumin derivatives are in the form of monomers, dimmers, and polymers.

Growing community of inventors

Staten Island, NY, United States of America

Probal Banerjee