University of Georgia Research Foundation Inc

Priyadarshini Singha

Hitesh Handa

Sean P Hopkins

Jason John Locklin

Marcus J Goudie

Jitendra Pant

Qiaohong Liu

Christina Danielle Workman

Coating compositions, coated articles including the coating compositions, and methods of making the coating compositions and coated articles are provided. In some aspects, the coating compositions are applied to a substrate having nitric oxide-releasing properties. The coating compositions can include copolymers having crosslinking agents that can be activated with mild UV light (about 345 nm to 365 nm) to avoid damaging the substrate while creating strong covalent bonds to the substrate. The copolymers can include hydrophilic repeat units, and in particular zwitterionic repeat units such as repeat units containing phosphorylcholine groups. In some aspects, the coating compositions are applied to a surface of a polymer substrate, wherein the polymer substrate had nitric oxide releasing properties. The coating compositions and the coated articles can have antifouling, antithrombotic, and/or antibacterial properties.

Surfaces and coating compositions having antifouling, antithrombotic, and antibacterial properties and methods of making

The present disclosure provides for modified antibiotic compounds, methods of making modified antibiotic compounds, methods of use, products including modified antibiotic compounds, and the like. The modified antibiotic compound comprises a nitric oxide release agent covalently attached to an antibiotic molecule, such as S-nitroso-N-acetylpenicillamine covalently attached to ampicillin.

Nitric oxide-releasing antibiotics, methods of making, and methods of use

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Athens, GA, United States of America

Priyadarshini Singha