University of California

University of South Florida

Altos Therapeutics, LLC

Millennium Pharmaceuticals Limited

Priyadarshini Jaishankar

Adam Renslo

Yu Chen

Orville Antonio Pemberton

Pascal Jean Druzgala

Gary W Luehr

Philip W Payne

Erica M W Lauterwasser

Arathi Sundaram

Derek Nichols

Xiujun Zhang

Kyle Defrees

Nicholas Joseph Torelli

Provided herein are heterocyclic compounds and pharmaceutical formulations that can be used to treat bacterial infections. Also provided herein are methods of making and using the heterocyclic compounds and pharmaceutical formulations.

Beta-lactamase inhibitors, formulations, and uses thereof

The present disclosure provides compositions including a beta-lactamase inhibitor, pharmaceutical compositions including a beta-lactamase inhibitor, methods of treatment of a condition (e.g., infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.

Compositions, methods of use, and methods of treatment

Embodiments of the present disclosure, in one aspect, relate to a beta-lactamase inhibitor, pharmaceutical compositions including a beta-lactamase inhibitor, methods of treatment of a condition (e.g., infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.

Provided are Dor Dantagonist compounds and pharmaceutical compositions of formula I and pharmaceutically acceptable salts thereof, or isomers thereof, wherein R, Rand Rare as defined herein. The invention further comprises methods for making the compounds of the invention and methods for the treatment of conditions mediated by the dopamine Dor Dreceptor from the compounds of the invention.

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Priyadarshini Jaishankar