International Business Machines Corporation

The University of Melbourne

The Florey Institute of Neuroscience and Mental Health

Priscilla Racquel Rogers

Natalie J Gunn

John Michael Wagner

Stefan Harrer

Jose Miguel Lobez Comeras

Ross Bathgate

Daniel Scott

Stan Skafidas

James R Kozloski

Ali Afzali-Ardakani

Julia S Baldauf

Christine Schieber

Stephen Michael Moore

Matthew Downton

Alexe Bojovschi

Sung Cheol Kim

Jose M Lobez Comeras

Matthew Downtown

A nanopore device for molecular characterization that includes a supporting substrate. The supporting substrate has at least one nanopore where the nanopore is a carbon nanotube of a first diameter. The nanodevice is configured to provide a stimulus to the carbon nanotube causing the first diameter to change to a second diameter. The nanopore device also includes a device configured to apply the stimulus to the nanopore. The nanopore device further includes an electrical circuit configured to measure an electrical property across the nanopore, where there is a change in the electrical property when a molecule traverses the nanopore.

Adjusting nanopore diameter in situ for molecule characterization

A process for monitoring binding events, a coating compound, and a device for monitoring binding events are disclosed. The process includes providing two reservoirs that contain an electrically conductive fluid, wherein the reservoirs are separated by a membrane having a nanopore. The process also includes selecting a target compound, selecting a ligand based on the selection of the target compound, and preparing a coating that includes the coating compound, wherein the coating compound includes the ligand and a moiety that immobilizes the ligand. Additionally, the process includes applying the coating to the inner surface of the nanopore, adding the target compound to a conductive liquid in the first chamber, establishing a voltage gradient across the membrane, and electrically monitoring translocation of the target molecule. The device includes the reservoirs and the membrane having the coated nanopore.

Nanopore coating for sensing chemical bond formation

Nanobubbles are employed to bridge microbubbles and non-buoyant particles, thereby creating sufficient capillary forces between the particles and microbubbles such that relatively large, heavy particles can be separated from an aqueous slurry. Nanobubbles are formed on hydrophobic particle surfaces. The microbubbles, which function as collecting air bubbles, form attachments with the particles. The nanobubbles create additional capillary attachment forces between the particles and microbubbles, allowing the microbubbles to rise with the attached particles to the top of the slurry for separation and recovery.

Nanobubbles for enhanced interaction between solids and gas volumes

A reusable coating for a nanopore structure is disclosed herein. A nanopore structure includes a substrate comprising a nanochannel and a monolayer of a chemical compound disposed onto at least a portion of a surface of the nanochannel. The chemical compound forms a reversible bond with at least one analyte binding compound introduced into the nanochannel. Methods for making and using the reusable coating are also disclosed.

Use of disulfide bonds to form a reversible and reusable coating for nanofluidic devices

A mechanism is provided for utilizing a nanodevice to distinguish molecules with different structure. The molecules translocate through or across a nanochannel filled with a electrolyte solution. An electrical signal through the nanochannel is measured for every translocation event. Inner surfaces of the nanochannel include a functional layer, which is a coating to functionalize the nanochannel, in which the functional layer is configured to interact with predetermined ones of the molecules during translocation events. It is determined that a combination of at least two different molecules is formed based on predetermined ones of the molecules interacting with the functional layer to change the electrical signal and/or change a translocation time for the translocation event.

Methods for determining binding capability of target ligands with G protein-coupled receptors using translocation through nanochannels

Modifying single proteins (GPCR), ligands, and nanopore surfaces to create binding-induced molecular changes of protein-ligand complexes detected in nanochannel translocation

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Fitzroy, Australia

Priscilla Racquel Rogers