Amgen Inc.

Premilla Arasasingham

Ning Chen

Mark Henry Norman

Christopher Harold Fotsch

Markian Myroslaw Stec

Liping H Pettus

Hui-Ling Wang

Xianghong Wang

Elizabeth M Doherty

Vassil I Ognyanov

Jiawang Zhu

Partha P Chakrabarti

Ning Xi

Michael G Kelly

Qingyian Liu

Nuria A Tamayo

Shimin Xu

Nianhe Han

Yunxin Y Bo

Martin H Goldberg

Duncan M Smith

Feng-Yin Hsieh

LipingH Pettus

Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

Vanilloid receptor ligands and their use in treatments

Selected substituted piperazine compounds of Formula Iare effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Substituted piperazinyl amides and methods of use

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Thousand Oaks, CA, United States of America

Premilla Arasasingham