Colgate Palmolive Company

Prem K Sreenivasan

Ravi Subramanyam

Nuran Nabi

Abdul Gaffar

John J Afflitto

Malcolm I Williams

Susan M Herles

Rolando B Plata

Fusong Sun

Neelima Utgikar

Manisha Jha

Shashank Potnis

The invention includes a method of distinguishing among oral bacteria species to determine whether a species is orally deleterious. Such method includes contacting at least one bacterium or portion of a bacterium of a species of oral bacteria a gingival cell; and detecting the presence of an indicator compound. The substantial absence of an indicator material signifies that the species of bacteria is not a deleterious species. Also included within the scope of the invention are methods for determining the anti-inflammatory effect of an agent. Such methods include contacting the cell with the agent in the presence of a deleterious bacterium or portion of such bacterium and detecting the presence of an indicator compound. The substantial absence of an indicator material signifies that agent is an anti-inflammatory agent.

Methods of modulating cell surface receptors to prevent or reduce inflammation

Antiplaque oral compositions are provided that contain an orally acceptable carrier and an antibacterial effective amount of the compound of formula (I). In various embodiments, the compositions contain from about 0.001% to about 10% by weight of the compound of formula (I).

Oral compositions containing biphenol antibacterial compounds

A stable antibacterial oral composition containing a hydrogenated lupulone and an anionic surfactant.

Stable hydrogenated lupulone antibacterial oral compositions

A method for enhancing the antiplaque efficacy of an antibacterial dentifrice, comprising preparing a multicomponent dentifrice composition having a first dentifrice component containing an antibacterial agent and manganese coordination complex compound, and a second dentifrice component containing a peroxide compound; maintaining the first and second dentifrice components separately prior to use; combining the dentifrice components and applying the two components to the teeth and periodontium, whereby the dentifrice provides enhanced inhibition of plaque growth.

Method to enhance the antibacterial efficacy of antibacterial dentifrices

Growing community of inventors

Westfield, NJ, United States of America

Prem K Sreenivasan