Brigham Young University

The United States of America As Represented by the United States

The United States of America As Represented by the Department of Energy

Prem C Srivastava

Roland K Robins

Furn F Knapp, Jr

A mercuric maleimide is utilized as a pharmaceutical kit for preparing radiohalogenated maleimides.

Mercuric acetate phenyl maleimide useful for preparing radiohalogenated

A class of radiolabeled compounds to be used in tissue imaging that exhibits rapid brain uptake, good brain:blood radioactivity ratios, and long retention times. The imaging agents are more specifically radioiodinated aromatic amines attached to dihydropyridine carriers, that exhibit heart as well as brain specificity. In addition to the radiolabeled compounds, classes of compounds are also described that are used as precursors and intermediates in the preparation of the imaging agents.

Precursors to radiopharmaceutical agents for tissue imaging

A radiopharmaceutical for antibody labeling comprising an iodophenyl maleimide that attaches thiol sites of proteins thereby maintaining bioreactivity largely located at the nitrogen sites.

Radioiodinated maleimides and use as agents for radiolabeling antibodies

A class of novel 2-.beta.-D-ribofuranosylselenazole-4-carboxamide nucleoside and nucleotide compounds and methods for their production are provided. Compounds of the class typically have pharmacological properties, especially antitumor and antiviral properties, and are well tolerated, being useful, for example, in treating tumors and viral infections in warm blooded animals.

2-.beta.-D-ribofuranosylselenazole-4-carboxamide compounds and methods

2-.beta.-D-ribofuranosylselenazole-4-carboxamide compounds

2-.beta.-D-Ribofuranosylthiazole-4-carboxamidine (I) and salts are provided as well as a means for their production and use. The compounds typically show unique pharmacological activity, especially antienzyme and cytotoxic activity. ##STR1##

Growing community of inventors

Oak Ridge, TN, United States of America

Prem C Srivastava