University System of Maryland

University of Virginia Patent Foundation

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Preeti Chhabra

Joel M Linden

Gordon W Laurie

Barbara J Mann

Thomas R Gadek

Kenneth Brayman

Yunge Zhao

Christine Lau

Mingyang Ma

Karina Teixeira

Kenneth Lewis Brayman

Jan Vinje

Sanford Feldman

Nicole Gregoricus

Leslie Barclay

Compositions and methods for regenerating pancreatic islet viability and/or cell proliferation in vitro, ex vivo, and/or in vivo; and/or for regenerating glucose-stimulated insulin secretion; and/or for regenerating viability and/or cell proliferation of a transplanted pancreatic islets; and/or for preventing and/or inhibiting rejection of a transplanted islets; and/or for pancreatic islet transplantation; and/or for treating a symptom of a condition, disorder, or disease associated with abnormal insulin responsiveness to glucose are provided. In some embodiments, the compositions include a peptide and/or a pharmaceutically acceptable salt thereof, and/or a biologically active fragment, analog, or derivative thereof, wherein the peptide, the pharmaceutically acceptable salt thereof, and/or the biologically active fragment, analog, or derivative thereof has an amino acid sequence of any of SEQ ID NOs: 1-60, or any combination thereof.

Compositions and methods for promoting islet viability and enhancing insulin secretion

The present invention relates methods of treating cytokine storm syndrome comprising administering to a patient in need thereof a therapeutically effective amount of an adenosine Areceptor agonist.

Adenosine A2A agonists for the treatment of cytokine storm syndrome

Growing community of inventors

Waynesboro, VA, United States of America

Preeti Chhabra