Novozymes A/s

Novozymes, Inc.

Albumedix A/s

Sartorius Albumedix Limited

Preethi Ramaiya

Randy M Berka

Michael W Rey

Michael Dolberg Rasmussen

Peter Bjarke Olsen

Jens Tønne Andersen

Allan Svendsen

Thomas Agersten Poulsen

Padmavathi Balumuri

Marco Malten

Christopher John Arthur Finnis

Vivek Srivastava

Vasudeva Prahlada Rao

Jennifer Mary McLaughlan

Per Kristoffer Nordeide

Beth Nelson

Hiroshi Teramoto

Kaihei Kojima

The invention provides an improved host strain for production of desired protein.

Protein expression strains

The present invention relates to glucoamylase variants, polynucleotides encoding the variants, methods of producing the variants, and methods of using the variants. Also described are the use of glucoamylases of the invention for starch conversion to produce fermentation products, such as ethanol, and syrups, such as glucose. The invention also relates to a composition comprising a glucoamylase variant of the invention.

Glucoamylase variants and polynucleotides encoding same

The instant invention relates to filamentous fungal host cells producing and secreting a heterologous polypeptide of interest, said mutant host cell comprising and expressing a mutated ireA gene or a homologue thereof encoding a modified IreA polypeptide or a homologue thereof, said modified IreA polypeptide or homologue thereof comprising amino acid substitutions in 5 positions corresponding to positions 81 and 84 in theIreA amino acid sequence shown in SEQ ID NO:16, as well as methods of producing a polypeptide of interest in said cells and methods for constructing said cells.

Filamentous fungal host

The present invention relates to glucoamylase variants having an increase in specific activity and/or an increase in melting temperature measured by TSA of at least 0.5 degrees Celsius, and further wherein the variants have at least at least 85%, at least 90%, at least 95% identity, at least 96%, at least 97%, at least 98%, or at least 99%, but less than 100%, sequence identity to the amino acid sequence of SEQ ID NO: 3. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

The present invention relates to an isolated polynucleotide of the complete chromosome of. The present invention also relates to isolated genes of the chromosome ofwhich encode biologically active substances and to nucleic acid constructs, vectors, and host cells comprising the genes as well as methods for producing biologically active substances encoded by the genes and to methods of using the isolated genes of the complete chromosome of

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Sunnyvale, CA, United States of America

Preethi Ramaiya