Roche Palo Alto LLC

F. Hoffmann-la Roche Ag

Pravin Iyer

Matthew C Lucas

Robert James Weikert

Ryan Craig Schoenfeld

Stephen Matthew Lynch

Clara Jeou Jen Lin

Ann Marie Madera

Marzia Villa

Kerem Erol Ozboya

David Michael Goldstein

Bernd Buettelmann

Leyi Gong

Joan Heather Hogg

Kristen Lynn McCaleb

Yun-chou Tan

Sarah C Abbot

Geneviève N Boice

Stephen M Lynch

Clara Jeou Lin

Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives and uses thereof

Compounds of formula I are effective modulators of JNK: wherein

Dihydroquinone and dihydronaphthridine inhibitors of JNK

This application discloses aminopiperidinyl compounds of generic Formulae I-II: or pharmaceutically acceptable salts thereof, wherein m, r, Q, Q, Q, R, R, R, R, R, and Rare defined as described herein, useful for treatment of diseases associated with monoamine reuptake inhibitors. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.

Aminopiperidinyl derivatives and uses thereof

Compounds of the formula: or pharmaceutically acceptable salts thereof,wherein m, n, Ar, R, R, Rand Rare defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.

Pyrrolidinyl and piperidinyl ketone derivatives and uses thereof

The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof,wherein p, Ar, R, R, R, R, R, R, Rand Rare defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.

3-amino-1-arylpropyl indoles and AZA-substituted indoles and uses thereof

The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R, R, R, R, R, R, Rand Rare defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.

3-amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof

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Mountain View, CA, United States of America

Pravin Iyer