Global Life Sciences Solutions USA LLC

Cytiva Sweden Ab

General Electric Company

Praveen Paul

Haresh Digambar Patil

Anoop Bhargav

Sebastian John

Manoj Kumar Ramakrishna

Manish Uddhaorao Choudhary

Prashanth Hosabettu Mohan

Pradeep R Kumar

Nivedita Phadke

Manjunath Bhat

Ajit S Vernekar

Swapnil Puranik

Krishnadev Madhavan Nair

Sahebagouda Alagur

Ajay Gore

A tray configured to be provided on a base station of a bioreactor system, said tray comprising a bottom and surrounding side walls and being configured to hold a bioreactor bag, said bottom comprising at least two bottom parts, whereof one is a middle part of the bottom, wherein at least one of the bottom parts is movable into at least a first and a second position, wherein said first position provides the bottom parts substantially flush with each other providing a substantially plane bottom of the tray and said second position provides a bottom of the tray having a recessed middle part.

Bioreactor tray

A perfusion bioprocessing system () includes a bioreactor () and a recirculation flow path () provided with at least in one first feed flow control device () and at least one second feed control device (). The perfusion bioprocessing system () further includes a first tangential flow filter () coupled to the bioreactor () via the recirculation flow path () and a second tangential flow filter () coupled to the bioreactor () via the recirculation flow path (). The first tangential flow filter and the second tangential flow filter are coupled to a permeate flow path and a retentate flow path. Additionally, the perfusion bioprocessing system () includes a control unit () coupled to the at least one first feed flow control device () and the at least one second feed control device ().

Perfusion bioprocessing system and method of operating the same

The present invention relates to a mixing system for a bioreactor, comprising a plurality of supply units (), each being able to hold media for use in a bioreactor a mixing unit () for creating a uniform mixing of media a first feeding mechanism (), arranged to feed media from the supply units () into the mixing unit (), a control unit () operatively connected to the first feeding mechanism () and the mixing unit (), said control unit () being configured to control the first feeding mechanism () to feed predetermined amounts of media from the plurality of supply units () to the mixing unit (), and further being configured to control the mixing unit () to create a uniform mixing of media. The invention also relates to a method for mixing media for use in a bioreactor.

Mixing system

A valve () for a bioprocess liquid apparatus () comprises tubular sections () inside which valve seat means () are arranged. A plunger arrangement () is configured to selectively interact with the valve seat means to close and open the tubular sections in response to a magnetic field provided by solenoid arrangements (), the solenoid arrangements being arranged at the bioprocess liquid apparatus. A flow path device comprising such a valve and a bioprocess liquid apparatus and a method of handling a bioprocess liquid are also disclosed.

Valve for a bioprocess liquid

Disclosed is a biomanufacturing apparatus () comprising a housing () including top () and bottom () faces which allow stacking of plural housings, an access door () at a front side of the housing, a substantially enclosed bioreactor chamber () inside the housing accessible via the door, and a further substantially enclosed region () inside the housing containing electrical parts and/or electronic control components, the chamber () including: a tray () for supporting a bioreactor, a tray support () including a mechanism () for rocking the tray in use; the tray having complementary formations allowing movement of tray relative to the tray support toward the front side to allow more convenient access to the bioreactor.

Biomanufacturing apparatus

Disclosed is biomanufacturing apparatuscomprising a housingincluding topand bottomfaces which allow stacking of plural housings, an access doorat a front side of the housing, a substantially enclosed bioreactor chamberinside the housing accessible via the door, and a further substantially enclosed regioninside the housing containing electrical parts and/or electronic control components, the chamberincluding: a trayfor supporting a bioreactor, a tray supportincluding a mechanismfor rocking the tray in use; the tray support further including a load cell () to determine changes in the mass load on the tray.

Disclosed is biomanufacturing apparatuscomprising a housingincluding topand bottomfaces which allow stacking of plural housings, an access doorat a front side of the housing, a substantially enclosed bioreactor chamberinside the housing accessible via the door, and a further substantially enclosed regioninside the housing containing electrical parts and/or electronic control components, the chamberincluding: a trayfor supporting a bioreactor, a tray supportincluding a mechanismfor rocking the tray in use; at least a fluid handling portionof at least one fluid pump device; and at least one connectionfor connecting to a conduit and/or path for carrying fluids, gas and/or electricity.

The present invention relates to a novel bioreactor system for cell cultivation. More specifically, the invention relates to a compact bioreactor system which has several integrated functions and enables small scale static culture as well as scale-up rocking culture in the same bioreactor. The bioreactor system comprises tray for positioning of a cell culture bag having adjustable volume, a lid covering the cell culture bag and provided with heating function, an integrated perfusion unit, an integrated cell loading unit, and an integrated unit for automatic cell culture sampling, wherein the bioreactor system is controlled by a single control unit. The invention also relates to a method of cell culture using the bioreactor system for culture of therapeutic cells.

Growing community of inventors

Bengaluru, India

Praveen Paul