The Brigham and Women's Hospital, Inc.

Massachusetts Institute of Technology

The City University of New York

The State University of New York

Praveen Kumar Vemula

Jeffrey Michael Karp

George John

Robert Samuel Langer

Omid C Farokhzad

Sufeng Zhang

Nathaniel R Campbell

Abdullah M Syed

Debanjan Sarkar

Pulickel Madhavapanicker Ajayan

Ashavani Kumar

Robert S Langer, Jr

Swapnil Jadhav

Greg Cruikshank

Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.

Nanostructured gels capable of controlled release of encapsulated agents

This invention discloses drug-delivery compositions, methods of making prodrugs, and methods of drug delivery using a self-assembled gelator. The backbone of the gelator can contain a drug or prodrug, such as acetaminophen or salicin. Additional drugs or agents can be encapsulated in the gelator. Enzymatic or hydrolytic cleavage can be used to release the drugs.

Drug delivery composition comprising a self-assembled gelator

The present invention relates to a method for thickening a hydrophobic liquid. When a hydrophobic liquid is thickened in accordance with the invention, the liquid becomes significantly denser. Preferably, the hydrophobic liquid becomes a gel.

Methods for thickening hydrophobic liquids with amphiphilic esters

Nanostructured gels capable of controlled release of entrapped agents

A composition includes an isolated cell; at least one particle within said cell; and at least one active agent associated with the particle, wherein the active agent is capable of being released from the cell. A method includes administration of such a cell to a subject.

Release of agents from cells

The present invention generally relates to a method of making nanoparticles and uses thereof. In particular, the invention relates to methods of making metal nanoparticles (MNPs). The invention also relates to antimicrobial uses of the nanoparticles.

Green approach in metal nanoparticle-embedded antimicrobial coatings from vegetable oils and oil-based materials

A method for preparing hydro/organo gelators from disaccharide sugars by biocatalysis and their use in enzyme-triggered drug delivery. Controlled delivery of an anti-inflammatory, chemopreventive drug is achieved by an enzyme-triggered drug release mechanism via degradation of encapsulated hydrogels. The hydro- and organo-gelators are synthesized in high yields from renewable resources by using a regioselective enzyme catalysis and a known chemopreventive and anti-inflammatory drug, curcumin, is encapsulated in the gel matrix and released by enzyme triggered delivery. The release of the drug occurs at the physiological temperature and control of the drug release rate is achieved by manipulating the enzyme concentration and temperature. The by-products formed after the gel degradation clearly demonstrated the site specificity of degradation of the gelator by enzyme catalysis. The present invention has applications in developing cost effective, controlled drug delivery vehicles from renewable resources, with a potential impact on pharmaceutical research and molecular design and delivery strategies.

Method for preparing hydro/organo gelators from disaccharide sugars by biocatalysis and their use in enzyme-triggered drug delivery

Agents from cells

Growing community of inventors

Cambridge, MA, United States of America

Praveen Kumar Vemula