Virginia Commonwealth University

Praveen Bhoopathi

Paul B Fisher

Devanand Sarkar

Swadesh K Das

Luni Emdad

Mitchell E Menezes

Xiang-yang Wang

Upneet Sokhi

Anjan K Pradhan

In various aspects, the present disclosure provides polynucleotides encoding a fusion protein, as well as vectors, cells, and compositions comprising the same. In embodiments, the fusion protein includes an insulin signal peptide and an MDA-7/IL-24 protein. Methods of using the polynucleotides, vectors, cells, and compositions, such as in the treatment or prevention of cancer, are also provided.

MDA-7/IL-24 secretory variants and methods of use

Recombinant therapeutic cytokines ('therakines') for the treatment of cancer are provided. The recombinant therakines include a truncated region of MDA-7/TL-24 ('M4') not normally found in nature that has anti-cancer activity and a secretory signal which causes secretion of the therakine from plasmid/virus transduced normal and cancer cells and interaction of the therakine to MDA-7/IL-24 receptors on adjacent, neighboring and distant cancer cells. Therakine interaction results in bystander killing of the target cancer cell as well as adjacent, neighboring and distant cancer cells.

Recombinant cancer therapeutic cytokine

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Richmond, VA, United States of America

Praveen Bhoopathi