Duke University

Pratiksha I Thakore

Charles A Gersbach

Joshua B Black

Isaac B Hilton

David G Ousterout

Pablo Perez-Pinera

Ami M Kabadi

The present disclosure provides Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use.

CRISPR/Cas9-based repressors for silencing gene targets in vivo and methods of use

Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.

RNA-guided gene editing and gene regulation

Growing community of inventors

Durham, IL, United States of America

Pratiksha I Thakore