Council of Scientific & Industrial Research

Evolva Sa

Other

Prathama Satyendra Mainkar

Srivari Chandrasekhar

Togapur Pavan Kumar

Ummanni Ramesh

Alexandra Santana Sorensen

Boggavarapu Subrahmanya Sastry

Peteris Alberts

Jerald Mahesh Kumar

Katragadda Suresh Babu

Jean-Philippe Meyer

Chandrasekhar Srivari

Pavan Kumar Togapur

Chada Raji Reddy

Kanchanapally Tejaswini

Melya Hughes Crameri

Karre Nagaraju

Thierry Bonnaud

Somesh Sharma

Debabrata Mukhopadhyay

Srihari Pabbaraja

Srigiridhar Kotamraju

Subhash Ghosh

Avula Shiva Krishna

Gangarajula Sudhakar

Kumaraguru Thenkrishnan

Rajesh Nasam

Pitchakuntla Mallesham

Karsten Kristiansen

Divya Duscharla

Subbarao Mohan Venkata Muppidi

Srinu Paladugu

Ashok Kumar Jha

Kondepudi Sugnana Sunder

Prem Kumar Arumugam

Mohammad Abdul Sattar

Joanne Kelleher

David Pearson

Subbarao Mohan Muppidi

Alexandra c/o Evolva Sa Santana Sorensen

The present invention relates to an enzymatic process for preparation of optically pure enantiomers of homopropargylic alcohol compounds of formula I, which are useful intermediates for the synthesis of Halichondrin B and analogs. wherein, P is H or an alcohol protecting group, n is an integer ranging from 0-12.

Chemo-enzymatic process for the preparation of homopropargylic alcohol

The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R, R, R, R, Rand Rare selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.

Nimbolide analogs as anti-cancer agents and preparation thereof

The present invention provides a compound of general formulae I useful as GSK3&#x3b2; inhibitors and their anticancer potential and process for preparation of these spirooxindoles. wherein

Spirooxindole compounds as GSK3B inhibitors and process for preparation thereof

Sulfonyl hydroxamic acid compounds have the following general formula: Ring A and B are aryl, heteroaryl, cycloalkyl, fused aryl or fused alkyl group, and R, R, R, R, R, and Rare hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl, aryl, heteroaryl, halogen, hydroxy, alkoxy, aryloxy, nitro, cyano, ester, or aldehyde. The compounds are HDAC inhibitors. Processes can be used for preparation of these indole-based sulfonyl hydroxamic acid derivatives.

Indole (sulfomyl) n-hydroxy benzamide derivatives as selective HDAC inhibitors

The present invention relates to a process for the preparation of (1-alkylindol-3-ylmethyl) benzoic acid derivatives, in particular Zafirlukast and analogs thereof. Further, this process is based on protection group free and C&#x2014;H bond activation strategy involving all step catalytic transformation sequence and comprises the following steps: Sonogashira coupling, indole formation by SpC&#x2014;H activation, reductive hydrogenation and amidation.

Process for the preparation of Zafirlukast and analogs thereof

The present invention relates to a process for the preparation of racemic nicotine from 3-pyridylaldehyde using a one-pot or step-wise method. The process comprises the following steps: Stetter reaction, reduction-cyclization and methylation.

Process for the preparation of nicotine

Specifically useful stereoisomers of 1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and infections as well as their use in the treatment of a disease related to TP, such as cardiovascular diseases. 

Substituted 1,3-dioxanes useful as PPAR modulators

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Hyderabad Telangana, India

Prathama Satyendra Mainkar