Case Western Reserve University

The Cleveland Clinic Foundation

Prateek Prasanna

Anant Madabhushi

Pallavi Tiwari

Sunil K Srivastava

Nathaniel Braman

Justis P Ehlers

Vamsidhar Velcheti

Kaustav Bera

Pranjal Vaidya

Niha Beig

Vinay Varadan

Marwa Ismail

Lyndsay Harris

Salendra Singh

Embodiments include controlling a processor to perform operations, the operations comprising accessing a digitized image of a region of tissue (ROT) demonstrating cancerous pathology; extracting a set of radiomic features from the digitized image, where the set of radiomic features are positively correlated with programmed death-ligand 1 (PD-L1) expression; providing the set of radiomic features to a machine learning classifier; receiving, from the machine learning classifier, a probability that the region of tissue will experience cancer recurrence, where the machine learning classifier computes the probability based, at least in part, on the set of radiomic features; generating a classification of the region of tissue as likely to experience recurrence or non-recurrence based, at least in part, on the probability; and displaying the classification and at least one of the probability, the set of radiomic features, or the digitized image.

Predicting recurrence and overall survival using radiomic features correlated with PD-L1 expression in early stage non-small cell lung cancer (ES-NSCLC)

Embodiments facilitate generation of a prediction of long-term survival (LTS) or short-term survival (STS) of Glioblastoma (GBM) patients. A first set of embodiments discussed herein relates to training of a machine learning classifier to determine a prediction for LTS or STS based on a radiographic-deformation and textural heterogeneity (r-DepTH) descriptor generated based on radiographic images of tissue demonstrating GBM. A second set of embodiments discussed herein relates to determination of a prediction of disease outcome for a GBM patient of LTS or STS based on an r-DepTH descriptor generated based on radiographic imagery of the patient.

Radiographic-deformation and textural heterogeneity (r-DepTH): an integrated descriptor for brain tumor prognosis

Embodiments discussed herein facilitate determination of tumor mutation status based on context and spatial information. One example embodiment can access a MRI scan of a tumor comprising voxels; extract radiomic feature(s) from the voxels; generate a spatial feature descriptor indicating probabilities the tumor has a first mutation status and a second mutation status, based on the MRI scan, a first population atlas for the first mutation status, and a second population atlas for the second mutation status; provide the radiomic feature(s) and the spatial feature descriptor to a machine learning model; and receive, via the machine learning model, a map indicating, for each voxel of the voxels, a probability of the first mutation status for that voxel and a probability of the second mutation status for that voxel, wherein the map is based at least on the one or more radiomic features and the spatial feature descriptor.

Spatial-and-context aware virtual biopsy radiogenomic maps to target tumor mutational status

Embodiments facilitate prediction of anti-vascular endothelial growth (anti-VEGF) therapy response in DME or RVO patients. A first set of embodiments discussed herein relates to training of a machine learning classifier to determine a prediction for response to anti-VEGF therapy based on a vascular network organization via Hough transform (VaNgOGH) descriptor generated based on FA images of tissue demonstrating DME or RVO. A second set of embodiments discussed herein relates to determination of a prediction of response to anti-VEGF therapy for a DME or RVO patient (e.g., non-rebounder vs. rebounder, response vs. non-response) based on a VaNgOGH descriptor generated based on FA imagery of the patient.

Hough transform-based vascular network disorder features on baseline fluorescein angiography scans predict response to anti-VEGF therapy in diabetic macular edema

Embodiments facilitate prediction of anti-vascular endothelial growth (anti-VEGF) therapy response in DME patients. A first set of embodiments discussed herein relates to training of a machine learning classifier to determine a prediction for response to anti-VEGF therapy based on a set of graph-network features and a set of morphological features generated based on FA images of tissue demonstrating DME. A second set of embodiments discussed herein relates to determination of a prediction of response to anti-VEGF therapy for a DME patient (e.g., non-rebounder vs. rebounder, response vs. non-response) based on a set of graph-network features and a set of morphological features generated based on FA imagery of the patient.

Predicting response to anti-vascular endothelial growth factor therapy with computer-extracted morphology and spatial arrangement features of leakage patterns on baseline fluorescein angiography in diabetic macular edema

Embodiments access a radiological image of tissue having a tumoral volume and a peritumoral volume; define a vasculature associated with the tumoral volume; generate a Cartesian two-dimensional (2D) vessel network representation; compute a first set of localized Hough transforms based on the Cartesian 2D vessel network representation; generate a first aggregated set of peak orientations based on the first set of Hough transforms; generate a spherical 2D vessel network representation; compute a second set of localized Hough transforms based on the spherical 2D vessel network representation; generate a second aggregated set of peak orientations based on the second set of Hough transforms; generate a vascular network organization descriptor based on the aggregated peak orientations; compute a probability that the tissue is a member of a positive class based on the vascular network organization descriptor; classify the ROI based on the probability; and display the classification.

Vascular network organization via Hough transform (VaNgOGH): a radiomic biomarker for diagnosis and treatment response

Methods, apparatus, and other embodiments distinguish disease phenotypes and mutational status using co-occurrence of local anisotropic gradient orientations (CoLIAGe) and Laws features. One example apparatus includes a set of circuits that acquires a radiologic image (e.g., MRI image) of a region of tissue demonstrating breast cancer, computes a gradient orientation for a pixel in the MRI image, computes a significant orientation for the pixel based on the gradient orientation, constructs a feature vector that captures a discretized entropy distribution for the image based on the significant orientation, extracts a set of texture features from the MRI image, and classifies the phenotype of the breast cancer based on the feature vector and the set of texture features. Embodiments of example apparatus may generate and display a heatmap of entropy values for the image. Example methods and apparatus may operate substantially in real-time, or may operate in two, three, or more dimensions.

Entropy-based radiogenomic descriptions on magnetic resonance imaging (MRI) for molecular characterization of breast cancer

Methods, apparatus, and other embodiments associated with distinguishing disease phenotypes using co-occurrence of local anisotropic gradient orientations (CoLIAGe) are described. One example apparatus includes a set of logics that acquires a radiologic image (e.g., MRI image) of a region of tissue demonstrating disease pathology (e.g., cancer), computes a gradient orientation for a pixel in the MRI image, computes a significant orientation for the pixel based on the gradient orientation, constructs a feature vector that captures a discretized entropy distribution for the image based on the significant orientation, and classifies the phenotype of the disease pathology based on the feature vector. Embodiments of example apparatus may generate and display a heatmap of entropy values for the image. Example methods and apparatus may operate substantially in real-time. Example methods and apparatus may operate in two or three dimensions.

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Cleveland, OH, United States of America

Prateek Prasanna