Telik, Inc.

Prasad V V S V Manchem

Steven R Schow

Robert T Lum

Songyuan Shi

Michael R Kozlowski

Wayne R Spevak

Louise Robinson

Jeong Weon Park

Nicolas Cairns

Compounds of formula I are useful for treating conditions associated with hyperglycemia, especially Type II diabetes. These compounds are useful in stimulating the kinase activity of the insulin receptor, activating the insulin receptor, and stimulating the uptake of glucose. Pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.

Naphthalene ureas as glucose uptake enhancers

Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds. These compounds, as single stereoisomers or mixtures of stereoisomers, or their pharmaceutically acceptable salts, are useful in methods of stimulating the kinase activity of the insulin receptor, enhancing the activation of the insulin receptor by insulin, and stimulating the uptake of glucose into cells. A variety of antidiabetic compounds and pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.

Naphthylsulfonic acids and related compounds as glucose uptake agonists

Compounds of Formula I, and pharmaceutical compositions containing these compounds, activate the insulin receptor kinase, which leads to an increased sensitivity to insulin and an increase in glucose uptake, and are therefore useful for the treatment of animals, especially humans, with hyperglycemia, especially for the treatment of type 2 diabetes. Processes for preparation of the compounds, and their use in assays, are also disclosed.

Benzene tricarboxylic acid derivatives as insulin receptor activators

A method for determining whether a compound is an insulin receptor kinase activator.

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Prasad V V S V Manchem