Novan, Inc.

Momentive Performance Materials Gmbh

Oregon State University

Allvivo Vascular, Inc.

Allvivio Vascular, Inc.

Pranav Ramchandra Joshi

Nathan Stasko

Susanne Bauman

Anubhav Saxena

Alok Sarkar

Jennifer A Neff

Joseph McGuire

Srividhya Marimuthu

Monjit Phukan

Sandeep Naik

Provided according to some embodiments of the invention are wound dressings that include a polymer matrix and nitric oxide-releasing polysiloxane macromolecules within and/or on the polymer matrix. Also provided are wound dressing kits and methods of using and forming such wound dressings.

Wound dressings, methods of using the same and methods of forming the same

Provided according to some embodiments of the invention are topical gels that may release nitric oxide. Also provided are methods of using such topical gels in the treatment of wounds and other skin ailments.

Topical gels and methods of using the same

The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the peptide with a block polymer, such as PLURONIC&#xae; F108 or an end group activated polymer (EGAP) in a manner to form a flexible tether and/or entrap the peptide. The entrapped peptide provides antimicrobial action by early release from entrapment while the tethered peptide provides longer lasting antimicrobial protection. Antimicrobial gels and foams may be prepared using the antimicrobial peptide containing block copolymers.

Antimicrobial constructs

Provided according to some embodiments of the invention are topical gels that may release nitric oxide. Also provided are methods of using such topical gels in the treatment of wounds and other skin ailments. The topical gels comprise diazeniutndiolate-functionalized polysiloxane macromolecules.

A silicone adhesive composition including an ionic silicone and useful for healthcare applications such as wound care and drug delivery.

Silicone adhesive compositions

A composition including an actinic radiation or thermally curable polyorganosiloxane ionomer having one or more reactive groups, for example, vinyl, acrylate, epoxy groups.

Free radical polymerizable compositions comprising ionic silicones

A polymer composite composition wherein at least one of the constituents is a silicone ionomer and the other constituent is polymer.

Polymer composites of silicone ionomers

A curable composition of ionic silicones includes a silicone having the formula MMMDDDTTTQhaving ionic groups and crosslinking functional groups. The composition can further include polyorganosiloxane having the average compositional formula RR(OH)SiO, organohydrogenoligosiloxane or organohydrogenpolysiloxane that has the average compositional formula HRSiOa transition metal catalyst and other components such as UV stabilizer, cure accelerator, pigment, dye, antimicrobial agent, biocide, surfactant, functional or non-functional filler, conductive filler, finely divided surface treated/untreated metal oxides, clay, plasticizers, tackifiers, mold release agents, adhesion promoters, compatibilizers, pharmaceutical excipients, surfactants or antistatic agents.

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Bengaluru, India

Pranav Ramchandra Joshi