King Fahd University of Petroleum and Minerals

Pran Kishore Deb

Katharigatta N Venugopala

Mohamed A Morsy

Bandar Aldhubiab

Sandeep Chandrashekharappa

Mahesh Attimarad

Nagaraja Sreeharsha

Anroop B Nair

Melendran Pillay

Rashmi Venugopala

Vinuta Kamat

Boja Poojary

Vijay M Kumbar

Manohar S Kugaji

Rangappa Santosh

Osama I Alwassil

Vijaykumar Uppar

Sheena Shashikanth

Raghu Prasad Mailavaram

Basavaraj Padmashali

Shashiprabha S

Nefisath P

Jagadeesh Prasad Dasappa

Christophe Tratrat

Nizar A Al-Shar'i

Keshab M Bairagi

Susanta K Nayak

Bapi Gorain

Swastika Ganguly

Lim Tse Mun

Gabriella Marucci

Buccioni Michela

Sandeep Chandrashekarappa

Annie Lee Pei Wen

Wafa Hourani

Goh Hui Shan

Bandar Adlhubiab

Jamie Kow Kean Hing

Compounds for treating a microbial and/or bacterial infection and, particularly, to compounds of formula 4 as identified below that are 5-(substitutedphenyl)-7-thioxo-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues and their use as anti-microbial or anti-bacterial agents, with the substituents defined as stated herein.

5-(substitutedphenyl)-7-thioxo-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues as antibacterial agents

Novel 1-(2-(substituted phenyl)-2-oxoethyl)-4-methylpyridin-1-ium bromide derivatives compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The 1-(2-(substituted phenyl)-2-oxoethyl)-4-methylpyridin-1-ium bromide derivatives compounds, are useful as anti-tubercular agents.

1-(2-(substituted phenyl)-2-oxoethyl)-4-methylpyridin-1-ium bromide as anti-tubercular agents

Novel 2-(substituted benzyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-ones and 4-fluoro-N-(4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)benzamide compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The 2-(substituted benzyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-ones and 4-fluoro-N-(4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)benzamide compounds, identified as COX-2 inhibitors, are useful as anti-inflammatory and pain agents.

Selective COX-2 inhibition of 2-(substituted benzyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-ones and 4-fluoro-n-(4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)benzamide as anti-inflammatory agents

Compounds for treating a microbial and/or bacterial infection and, particularly, to compounds that are 5-(substituted phenyl)-7-thioxo-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues and their use as anti-microbial or anti-bacterial agents. The compounds having the formula 4:

Compounds for treating tuberculosis and, particularly, to anti-tubercular compounds that are (E)-1-(2-(4-substitutedphenyl)-2-oxoethyl)-4-((hydroxyimino)methyl)pyridinium bromides and their use as anti-tubercular agents.

(e)-1-(2-(4-substitutedphenyl)-2-oxoethyl)-4-((hydroxyimino)methyl)pyridinium bromides as antitubercular agents

Compounds for treating an inflammatory disease, disorder, or condition and, particularly, to compounds that are 5-(substitutedphenyl)-7-imino-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues and their use as anti-inflammatory agents.

5-(Substitutedphenyl)-7-Imino-7,8-Dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues as anti-inflammatory agents

Novel arylhydrazones derivatives, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The arylhydrazones derivative compounds are useful as anti-tubercular agents.

(E)-2-(3-Cyano-4-isobutoxyphenyl)-N'-(substituted benzylidene)-4-methylthiazole-5-carbohydrazides as anti-tubercular agents

(E)-2-(3-cyano-4-isobutoxyphenyl)-n'-(substituted benzylidene)-4-methylthiazole-5-carbohydrazides as anti-tubercular agents

Compounds for treating tuberculosis and, particularly, anti-tubercular compounds that are substituted 1,3,4-oxadiazole derivatives and their use as anti-tubercular agents are provided.

Substituted 1,3,4-oxadiazole derivatives as anti-tubercular agents

Compounds for treating tuberculosis and, particularly, anti-tubercular compounds that are (6-methyl-4-substitutedphenyl-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(piperidin-1-yl)methanones and their use as anti-tubercular agents are provided.

(6-methyl-4-substitutedphenyl-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(piperidin-1-yl)methanones as antitubercular agents

Compounds for treating a microbial infection and/or tuberculosis and, particularly, antimicrobial and/or antitubercular compounds that are 3-cyano 4,5-diphenyl furan-2-carboxamides and their use as antimicrobial and/or antitubercular agents are provided.

3-cyano 4,5-diphenyl furan-2-carboxamides as antitubercular agents

Compounds for treating preventing malaria and, particularly, to larvicidal agents that are 7-isopropyl 1-ethyl/methyl 3-(substituted benzoyl)-2-substituted indolizine-1,7-dicarboxylates derivatives and their use as larvicidal agents.

7-isopropyl 1-ethyl/methyl 3-(substituted benzoyl)-2-substituted indolizine-1,7-dicarboxylates as larvicidal agents

Novel oxoimidazolidine derivative compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The oxoimidazolidine derivative compounds are useful as anti-tubercular agents.

Oxoimidazolidine derivatives as anti-tubercular agents

Adenosine receptor active compounds including 1,2,3,6,8-pentasubstituted indolizines and methods of using the same for inhibiting adenosine receptor activity are provided. These methods can be used to treat one or more pathological conditions of the central and peripheral nervous systems, such as but not limited to allergies, inflammation, glaucoma, brain ischemia, renal fibrosis, cancer, rheumatoid arthritis, psoriasis fatty liver diseases, stroke, pain, and any combination thereof.

Adenosine receptor activity of methyl/ethyl 3-(substituted benzoyl)-6,8-dimethylindolizine-2-substituted-1-carboxylates

Compounds for treating tuberculosis and, particularly, to anti-tubercular compounds that are substituted 7-amino-3-(substituted benzoyl)indolizine-1-carboxylates and their use as anti-tubercular agents.

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Ranchi, India

Pran Kishore Deb