Piramal Enterprises Limited

Piramal Life Sciences Limited

Pramod Kumar Jadhav

Meenakshi Sivakumar

Manoj Shukla

Kalpana Sanjay Joshi

Maggie Rathos

Malcolm Mascarenhas

Ankush Gangaram Sarde

Ajit Borhade

Ankush Sarde

The present invention relates to an enantiomerically pure (+)-trans enantiomer of a compound represented by the following formula (I): wherein R, R, R, Rand Rare as defined in the specification; enantiomerically pure intermediates thereof, to processes for the preparation of the enantiomerically pure compound and its intermediates, and to a pharmaceutical composition comprising the enantiomerically pure compound. The compound of formula (I) is useful for the treatment of diseases or disorders mediated by the inhibition of cyclin dependant kinase, such as cancer.

Enantiomerically pure compounds for the treatment of proliferative disorders

The present invention relates to an enantioselective synthesis of (+)-trans enantiomer of pyrrolidines substituted with flavones, represented by Formula 1 or salts thereof, which are inhibitors of cyclin dependant kinases and can be used for treatment of proliferative disorders such as cancer wherein Ar has the meaning as indicated in the claims.

Enantioselective synthesis of pyrrolidines substituted with flavones, and intermediates thereof

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Maharashtra, India

Pramod Kumar Jadhav